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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: J Endocrinol. 2025 May 7;265(3):e240318. doi: 10.1530/JOE-24-0318

Figure 4. Non-neuronal cells are scarce contributors to de novo neurosteroid biosynthesis.

Figure 4.

(A). Cropped t-SNE label plots showing OPC-Oligo, Immune, Astro-Epen and Vascular and t-SNE expression plots for Cyp11a1, Cyp27a1, Pdgfra, Mog, Gfap, C1qa, Cd93 and Pdgfrb (color range indicates quartiles). (B) Co-expression of Cyp11a1 and Cyp27a1 with different non-neuronal cells (based on markers) are presented as a percentage of the total population of non-neuronal cells. Evaluating Cyp11a1 and Cyp27a1 expression together with co-expression of different non-neuronal cell lineages indicated a higher degree of bile acid biosynthetic capacity and diminutive de novo neurosteroidogenic capacity in these cells. (C) Distribution of Cyp27a1 expressing non-neuronal cells were primarily associated with OPC-Oligo with minor populations of Astro-Epen, Immune and Vascular cells.