Figure 2:

A schematic diagram of intercellular communication in COC (10)

A: Demonstrations connected pathways of metabolism and meiosis in COC, B: shows role of OSFs which can be transported by EVs or directly get into cumulus cells through the membrane fusion

PPP: Pentose phosphate pathway; NADPH: Nicotinamide adenine dinucleotide phosphate; cAMP: Cyclic adenosine monophosphate; cGMP: Cyclic guanosine monophosphate; CDK1: Cyclin-dependent kinase 1; OSFs: Oocyte secreted factors; PRPP: phosphoribosyl pyrophosphate; PDE: phosphodiesterase; MPF: maturation promoting factor; ATP: Adenosine triphosphate