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. Author manuscript; available in PMC: 2026 Jun 10.
Published in final edited form as: Mol Cell. 2025 Jun 10;85(12):2442–2451.e5. doi: 10.1016/j.molcel.2025.05.020

Figure 2. Some of chromatin loops are reduced in ΔVostok mutants.

Figure 2.

(A) Differential loop strength analysis of all larval brain loops yw vs ΔVostok mutants, highlighting significantly altered loops (cyan).

(B) A total of 47 out of 645 chromatin loops show reduced strength in ΔVostok mutants.

(C) Of these, 19 reduced loops are associated with decreased Vostok protein binding.

(D, F) Micro-C maps illustrating reduced loops at the kek1 locus (D) and the NetA-NetB locus (F) in ΔVostok mutants.

(E, G) Corresponding reductions in Vostok binding at the kek1 (E) and NetA-NetB (G) loci in ΔVostok mutants. The positions of tethering elements and genes are shown at the bottom of the maps.