Table 1.
Baseline characteristics of study participants.
| All CHD (n=247) | SV (n=114) | d-TGA (n=92) | ToF (n=41) | Non-CHD (n=94) | |
|---|---|---|---|---|---|
| Variables |
Mean (SD), Number (%), or Median [IQR] |
||||
|
| |||||
| Gestational age, weeks | 39.3 (2.1) | 38.8 (2.4) | 39.9 (1.3) | 39.4 (2.4) | 39.6 (1.2) |
| Self-reported white race | 221 (89) | 107 (94) | 81 (88) | 33 (80) | 75 (80) |
| Family social class | 48.4 (12.9) | 48.9 (13.8) | 47.1 (12.5) | 50.4 (10.9) | 53.4 (9.9) |
| Genetic diagnosis | 16 (6) | 10 (9)† | 0 | 6 (15)‡ | - |
| Age at first operation, days | 7 [4, 47] | 6 [3, 27] | 6 [4, 9] | 163 [76, 337] | - |
| DHCA duration, minutes | 35 (25)* | 39 (29)§ | 36 (22) | 26 (26)** | - |
| Total support time, minutes | 129 (40)* | 125 (49)§ | 142 (31) | 96 (27)** | - |
| Number of perioperative complications | 1 [0, 2] | 1 [0, 2] | 1 [0, 2] | 0 [0, 1] | - |
| Any neurological event | 51 (21) | 26 (23) | 20 (22) | 5 (12) | - |
| Number of catheterizations | 2 [1, 4] | 4 [3, 5] | 1 [0, 1] | 1 [0, 2] | - |
| Number of operations | 2 [1, 3] | 3 [3, 3] | 1 [1, 1] | 1 [1, 2] | - |
| Age at MRI, years | 15.0 (2.2) | 14.8 (3.0) | 15.7 (0.8) | 14.4 (1.0) | 15.1 (1.9) |
CHD: congenital heart disease, DHCA: deep hypothermic circulatory arrest, d-TGA: d-transposition of the great arteries, MRI: magnetic resonance imaging, SV: single ventricle, ToF: Tetralogy of Fallot
All variables are missing <3% unless otherwise noted.
Data is missing for 23 out of 247 participants (9%) and not relevant for 49 participants undergoing closed surgery.
Previously known genetic/phenotypic syndromes included VACTERL (n=1), VATER (n=1), 22q11 (n=1), CHARGE syndrome (n=1), Kartagener syndrome (n=1), Factor V Deficiency (n=1), Factor V Leiden Deficiency (n=1), Factor VII Deficiency (n=1), balanced translocation involving chromosomes 13 and 14 (n=1) and unspecified (n=1).
Data missing for 14 of 65 participants (22%) undergoing open surgery and not relevant for 49 participants undergoing closed surgery.
Previously known genetic/phenotypic syndromes included 22q11 (n=1), VATER (n=2), VACTERL (n=2), and Alagille syndrome (n=1).
Data missing for 9 out of 41 participants (22%).