Table 2. Comparison of clinical outcomes of study participants at baseline and follow-up (main analysis).
| Variables | Total (n=88) | Intervention (n=41) | Control (n=47) | P value |
|---|---|---|---|---|
| Baseline, median (IQR) | ||||
| mMRCa dyspnea scale | 1.0 (1.0‐2.0) | 1.0 (1.0‐2.0) | 1.0 (1.0‐1.8) | .40 |
| 6MWDb (m) | 483.5 (444.0‐520.0) | 495.0 (460.0‐541.3) | 480.0 (440.0‐503.8) | .10 |
| HADSc | 9.0 (6.0‐14.0) | 10.0 (7.0‐14.3) | 8.5 (5.0‐14.0) | .16 |
| SGRQd | ||||
| Total | 30.3 (20.1‐39.6) | 26.5 (18.8‐36.5) | 32.8 (20.6‐41.2) | .18 |
| Symptoms | 44.1 (33.5‐54.9) | 41.7 (30.1‐53.8) | 48.5 (33.6‐57.5) | .13 |
| Activity | 45.2 (32.2‐57.9) | 44.4 (30.5‐53.9) | 50.7 (32.4‐63.5) | .24 |
| Impacts | 15.5 (7.3‐28.3) | 13.0 (5.9‐25.8) | 18.3 (8.3‐30.7) | .26 |
| Follow-up, median (IQR) | ||||
| mMRC dyspnea scale | 1.0 (1.0‐1.0) | 1.0 (1.0‐1.0) | 1.0 (1.0‐1.0) | .35 |
| 6MWD (m) | 485.0 (460.0‐544.0) | 490.0 (468.8‐556.3) | 485.0 (440.0‐527.3) | .35 |
| HADS | 10.0 (5.0‐14.0) | 10.0 (5.0‐13.3) | 10.0 (4.3‐15.0) | .70 |
| SGRQ | ||||
| Total | 30.9 (18.5‐44.6) | 27.9 (17.6‐43.7) | 33.5 (22.1‐44.8) | .21 |
| Symptoms | 44.8 (32.4‐61.2) | 44.9 (25.2‐54.1) | 44.6 (33.2‐65.4) | .34 |
| Activity | 50.7 (31.5‐64.0) | 44.4 (25.7‐57.8) | 51.6 (40.1‐64.9) | .12 |
| Impacts | 16.9 (5.9‐30.1) | 13.8 (5.1‐27.2) | 18.0 (7.8‐31.2) | .34 |
a
mMRC: modified Medical Research Council.
b
6MWD: 6-minute walk test distance.
c
HADS: Hospital Anxiety and Depression Scale.
d
SGRQ: St George’s Respiratory Questionnaire.