Table 3. Comparison of clinical outcomes of study participants at baseline and follow-up (compliance ≥70%, per-protocol analysis).
| Variables | Total (n=62) | Intervention (n=15) | Control (n=47) | P value |
|---|---|---|---|---|
| Baseline, median (IQR) | ||||
| mMRCa dyspnea scale | 1.0 (1.0‐2.0) | 1.0 (1.0‐1.8) | 1.0 (1.0‐1.8) | >.99 |
| 6MWDb (m) | 480.0 (440.0‐520.0) | 480 (421.3‐551.8) | 480.0 (440.0‐503.8) | .65 |
| HADSc | 9.0 (5.8‐14.0) | 9.0 (6.3‐16.0) | 8.5 (5.0‐14.0) | .54 |
| SGRQd | ||||
| Total | 31.4 (20.2‐39.5) | 26.5 (19.5‐36.0) | 32.8 (20.6‐41.2) | .26 |
| Symptoms | 46.8 (33.5‐54.1) | 38.0 (19.5‐53.4) | 48.5 (33.6‐57.5) | .16 |
| Activity | 50.7 (33.0‐58.6) | 44.4 (44.4‐56.2) | 50.7 (32.4‐63.5) | .66 |
| Impacts | 16.3 (7.8‐30.4) | 12.1 (6.1‐17.5) | 18.3 (8.3‐30.7) | .23 |
| Follow-up, median (IQR) | ||||
| mMRC dyspnea scale | 1.0 (1.0‐1.0) | 1.0 (1.0‐1.0) | 1.0 (1.0‐1.0) | .29 |
| 6MWD (m) | 485.0 (440.0‐538.0) | 485.0 (463.3‐558.8) | 485.0 (440.0‐527.3) | .54 |
| HADS | 10.5 (5.0‐15.0) | 11.0 (5.0‐15.0) | 10.0 (4.3‐15.0) | .90 |
| SGRQ | ||||
| Total | 31.2 (18.5‐44.8) | 27.9 (15.2‐42.4) | 33.5 (22.1‐44.8) | .22 |
| Symptoms | 41.0 (30.6‐62.8) | 36.8 (21.2‐53.1) | 44.6 (33.2‐65.4) | .12 |
| Activity | 51.4 (33.1‐64.1) | 44.4 (22.6‐56.2) | 51.6 (40.1‐64.9) | .13 |
| Impacts | 17.5 (6.7‐31.5) | 12.8 (4.3‐33.7) | 18.0 (7.8‐31.2) | .44 |
a
mMRC: modified Medical Research Council.
b
6MWD: 6-minute walk test distance.
c
HADS: Hospital Anxiety and Depression Scale.
d
SGRQ: St George’s Respiratory Questionnaire.