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. 2002 Mar;68(3):1071–1081. doi: 10.1128/AEM.68.3.1071-1081.2002

FIG. 8.

FIG. 8.

Carbon flow through central metabolism in KO11 at the pyruvate node. Unless noted otherwise, enzymes are native to E. coli. Enzymes: 1, pyruvate kinase (pykA, pykF); 2, pyruvate formate-lyase (pflB); 3, pyruvate dehydrogenase (aceEF, lpd); 4, phosphotransacetylase (pta); 5, acetate kinase (ackA); 6, alcohol/aldehyde dehydrogenase (adhE); 7, Z. mobilis pyruvate decarboxylase (pdc); 8, Z. mobilis alcohol dehydrogenase II (adhB) and E. coli alcohol/aldehyde dehydrogenase (adhE); 9, lactate dehydrogenase (ldhA); 10, phosphoenolpyruvate carboxylase (ppc); 11, citrate synthase (gltA); 12, aconitase (acn); 13, isocitrate dehydrogenase (icd); 14, glutamate synthase (gltB, gltD); 15, glutamine synthetase (glnA); 16, malate dehydrogenase (mdh); 17, fumarase (fumB); 18, fumarate reductase (frdABC); 19, aspartate transaminase (aspA); 20, aspartase (aspC). The arrows beneath citrate synthase indicate inhibition of activity by NADH and antagonism of NADH inhibition by acetyl-CoA.