Table 1. Prediction of deleterious nonsynonymous single-nucleotide polymorphisms of the ADAM17^a gene using SIFT^b and PolyPhen.

Variant ID	Amino acid mutation	SIFT score	SIFT class	PolyPhen score	PolyPhen class
						rs1394373815	P 556 L	0	Deleterious	0.997	Probably damaging
rs542316178	G 550 D	0	Deleterious	0.987	Probably damaging
rs777478676	V 483 A	0	Deleterious	0.987	Probably damaging
rs951262662	G 479 E	0	Deleterious	0.996	Probably damaging
rs1192348585	G 349 E	0.01	Deleterious	1	Probably damaging
rs1157021454	T 339 P	0	Deleterious	1	Probably damaging
rs768704961	D 232 E	0	Deleterious	1	Probably damaging

^aADAM: A disintegrin and metalloprotease.

^bSIFT: Sorting Intolerant From Tolerant.