Table 2. Prediction of deleterious nonsynonymous single-nucleotide polymorphisms of ADAM17^a gene using PROVEAN^b, Mutation Assessor, and SNAP2^c.

Variant ID	Amino acid mutation	PROVEAN		Mutation Assessor		SNAP2
Score	Prediction	Score	Prediction	Score	Prediction
rs1394373815	P 556 L	−8.978	Deleterious	4.095	High	37	Effect
rs542316178	G 550 D	−6.068	Deleterious	4.83	High	76	Effect
rs777478676	V 483 A	−3.496	Deleterious	4.215	High	43	Effect
rs951262662	G 479 E	−7.119	Deleterious	4.78	High	89	Effect
rs1192348585	G 349 E	−7.269	Deleterious	3.83	High	83	Effect
rs1157021454	T 339 P	−5.606	Deleterious	3.735	High	69	Effect
rs768704961	D 232 E	−3.795	Deleterious	3.79	High	84	Effect

^aADAM: A disintegrin and metalloprotease.

^bPROVEAN: Protein Variation Effect Analyzer.

^cSNAP2: Screening for Non-Acceptable Polymorphisms 2.