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. 2025 Aug 25;6:e72133. doi: 10.2196/72133

Table 3. Prediction of the deleterious effects of nonsynonymous single-nucleotide polymorphisms related to SARS-CoV-2 using SIFTa and PolyPhen.

Variant ID Amino acid mutation SIFT score SIFT class PolyPhen score PolyPhen class
rs765452935 Q658H 0.01 Deleterious 0.003 Benign
rs144657795 D657G 0 Deleterious 0.097 Benign
rs758594009 D654N 0 Deleterious 0.063 Benign
rs780262610 F652L 0.81 Tolerated 0.015 Benign
a

SIFT: Sorting Intolerant From Tolerant.