Table 4. Prediction of the deleterious effects of nonsynonymous single-nucleotide polymorphisms related to SARS-CoV-2 using PANTHERa, SNP&GOb, and PhD-SNPc.
| Variant ID | Amino acid mutation | PANTHER | SNP&GO | PhD-SNP | ||||
|---|---|---|---|---|---|---|---|---|
| PSEPd | Prediction | Pdel | Reliability index | Prediction | Reliability index | Prediction | ||
| rs765452935 | Q658H | 220 | Possibly damaging | .50 | 6 | Neutral | 3 | Neutral |
| rs144657795 | D657G | 455 | Probably damaging | .57 | 2 | Neutral | 3 | Disease |
| rs758594009 | D654N | 1036 | Probably damaging | .85 | 1 | Neutral | 5 | Neutral |
| rs780262610 | F652L | 220 | Possibly damaging | .50 | 8 | Neutral | 6 | Neutral |
a
PANTHER: Protein Analysis Through Evolutionary Relationships.
b
SNP&GO: Single Nucleotide Polymorphisms and Gene Ontology.
c
PhD-SNP: Predictor of Human Deleterious Single Nucleotide Polymorphisms.
d
PSEP: Position-Specific Evolutionary Preservation.