Table 5. Prediction of ADAM17^a stability using MUpro and I-Mutant tools.

Mutation	MUpro		I-Mutant
Delta G	Prediction	Delta G	Prediction
P 556 L	0.20231915	Increase	−0.51	Decrease
G 550 D	−0.35202875	Decrease	−0.76	Decrease
V 483 A	−2.5029256	Decrease	−1.4	Decrease
G 479 E	−0.20347724	Decrease	−0.8	Decrease
G 349 E	−0.096611232	Decrease	−0.48	Decrease
T 339 P	−1.4271878	Decrease	−0.63	Decrease
D 232 E	−1.1774927	Decrease	−0.58	Decrease

^aADAM: A disintegrin and metalloprotease.