Table 3:
Discharge outcomes of all infants, Risk +, and PH positive infants that survived to discharge.
| Discharge Outcomes | All Infants Pre-Screen (n=501) | All Infants Post-Screen (n=535) | p-value | Risk+ Pre-Screen (n=258) | Risk+ Post-Screen (n=264) | p-value | PH+ Pre-Screen (n=54) | PH+ Post-Screen (n=86) | p-value |
|---|---|---|---|---|---|---|---|---|---|
| Discharge CGA, wks | 38.4 (34.0–87.4) | 38.7 (34.4–64.9) | 0.45 | 40.4 (34.9–87.4) | 40.7 (35.3–64.9) | 0.23 | 43.6 (36.7–87.4) | 41.7 (36.6–64.9) | 0.02** |
| Length of stay, days | 65.0 (28–407) | 67.0 (20–433) | 0.53 | 90.5 (35–407) | 97.0 (28–433) | 0.07 | 127 (49–407) | 113.5 (46–433) | 0.03** |
| Growth failure at discharge or death (weight Z ≤ −1.28) | 147/513 (28.7%) | 151/544 (27.8%) | 0.75 | 93/270 (34.4%) | 86/273 (31.5%) | 0.47 | 22/59 (37.3%) | 24/90 (26.7%) | 0.17 |
| NICU Death | 12/513 (2.3%) | 9/544 (1.7%) | 0.51 | 12/270 (4.4%) | 9/273 (3.3%) | 0.51 | 5/59 (8.5%) | 4/90 (4.4%) | 0.48 |
| Medications | |||||||||
| Sildenafil | 3 (0.6%) | 9 (1.7%) | 0.15 | 3 (1.2%) | 9 (3.4%) | 0.14 | 3 (5.6%) | 7 (8.1%) | 0.74 |
| Inhaled steroids | 21 (4.2%) | 37 (6.9%) | 0.06 | 21 (8.1%) | 36 (13.6%) | 0.05** | 14 (25.9%) | 22 (25.6%) | 1 |
| Furosemide | 12 (2.4%) | 17 (3.2%) | 0.46 | 11 (4.3%) | 15 (5.7%) | 0.55 | 7 (13.0%) | 9 (10.5%) | 0.79 |
| Thiazide | 113 (22.6%) | 75 (14.0%) | <0.001** | 94 (36.4%) | 67 (25.4%) | 0.008** | 38 (70.4%) | 36 (41.9%) | 0.002** |
| Spironolactone | 108 (21.6%) | 75 (14.0%) | 0.002** | 90 (34.9%) | 67 (25.4%) | 0.02** | 36 (66.7%) | 35 (40.7%) | 0.003** |
| Reflux medications | 93 (18.6%) | 91 (17.0%) | 0.52 | 69 (26.7%) | 68 (25.8%) | 0.84 | 21 (38.9%) | 29 (33.7%) | 0.59 |
| Respiratory support | 0.15 | 0.15 | 0.02** | ||||||
| Room air | 470 (93.8%) | 504 (94.2%) | 227 (88.0%) | 233 (88.3%) | 32 (59.3%) | 67 (77.9%) | |||
| Low flow O2 | 22 (4.4%) | 28 (5.2%) | 22 (8.5%) | 28 (10.6%) | 14 (25.9%) | 16 (18.6%) | |||
| Tracheostomy | 9 (1.8%) | 3 (0.56%) | 9 (3.5%) | 3 (1.1%) | 8 (14.8%) | 3 (3.5%) | |||
| Feeding | <0.001** | 0.004** | 0.95 | ||||||
| All PO | 396 (79.0%) | 380 (71.0%) | 169 (65.5%) | 145 (54.9%) | 21 (38.9%) | 33 (38.4%) | |||
| PO + Tube | 85 (17.0%) | 105 (19.6%) | 69 (26.7%) | 75 (28.4%) | 20 (37.0%) | 34 (39.5%) | |||
| Tube only | 20 (4.0%) | 47 (9.4%) | 20 (7.6%) | 44 (16.7%) | 13 (24.1%) | 19 (22.1%) | |||
| Readmission within 6 months | 92 (18.4%) | 68 (12.7%) | 0.01** | 56 (21.7%) | 40 (15.4%) | 0.06 | 16 (32.7%) | 16 (19.5%) | 0.10 |
Outcome statistics excludes NICU deaths. Data presented as n(%), median(range)
**
p < 0.05
PH = pulmonary hypertension, CGA = corrected gestational age, NICU = neonatal intensive care unit