Table 2.
Associations of 12 Proteins With CAA When Examined Together in 1 Model
| Proteins remained in the model after backward elimination | ||||
| Uniprot ID | Gene | Protein name | Association with CAA | |
| OR (95% CI) | p Value | |||
| Q9H4F8 | SMOC1 | Secreted modular calcium-binding protein 1 | 2.63 (1.93–3.59) | <0.001 |
| Q92765 | FRZB | Secreted frizzled-related protein 1 | 2.76 (1.69–4.50) | <0.001 |
| P02649 | APOE | Apolipoprotein E | 2.35 (1.43–3.87) | <0.001 |
| APOE4 | APOE4 | Apolipoprotein E4 | 1.22 (1.09–1.36) | <0.001 |
| Proteins removed from the model during backward elimination | ||||
| Uniprot ID | Gene | Protein name | Step of removal | p Value |
| Q92743 | HTRA1 | High-temperature requirement A serine peptidase 1 | 1 | 0.97 |
| Q9NRN5 | OLFML3 | Olfactomedin-like protein 3 | 2 | 0.83 |
| P21246 | PTN | Pleiotrophin | 3 | 0.74 |
| P21741 | MDK | Midkine | 4 | 0.68 |
| O95631 | NTN1 | Netrin-1 | 5 | 0.75 |
| P35625 | TIMP3 | Metalloproteinase inhibitor 3 | 6 | 0.64 |
| P02743 | APCS | Serum amyloid P-component | 7 | 0.56 |
| P06727 | APOA4 | Apolipoprotein A-IV | 9a | 0.095 |
Abbreviations: CAA = cerebral amyloid angiopathy; OR = odds ratio.
In a single ordinal logistic regression with backward elimination, 12 proteins we included as the model terms and CAA was the outcome. The model was controlled for age at death and sex.
a
During step 8, sex was removed from the model. Age at death remained in the model together with the 4 proteins in the top 4 rows.