Table 2.

Correlation Matrix of EPVS, WMHs, Lacunes, and Cerebral MBs With Neuroimaging and Blood-Based Biomarkers

Variable	EPVS (Staals)	WMH (Staals)	Lacunes (Staals)	MB (Staals)
MRI markers
GM/TIV	−0.100** (−0.156 to −0.031)	−0.288** (−0.344 to −0.233)	−0.192** (−0.249 to −0.126)	−0.174** (−0.229 to −0.107)
WM/TIV	−0.161** (−0.220 to −0.096)	−0.188** (−0.252 to −0.124)	−0.117** (−0.174 to −0.046)	−0.144** (−0.201 to −0.075)
Total GM perfusion (mL/min/100 g)	−0.040 (−0.104 to 0.024)	−0.116** (−0.175 to −0.044)	−0.140** (−0.207 to −0.065)	0.003 (−0.074 to 0.069)
BBM
Aβ42 (pg/mL)	−0.008 (−0.071 to 0.057)	0.072* (0.015 to 0.142)	−0.007 (−0.071 to 0.057)	0.027 (−0.028 to 0.090)
Aβ40 (pg/mL)	0.056 (−0.011 to 0.120)	0.165** (0.100 to 0.229)	0.067* (−0.002 to 0.130)	0.097** (0.032 to 0.160)
Aβ42/Aβ40 (ratio)	−0.077* (−0.144 to −0.006)	−0.084* (−0.149 to −0.017)	−0.086* (−0.147 to −0.023)	−0.069* (−0.135 to −0.002)
OAβ (ratio)	0.012 (−0.077 to 0.092)	0.062 (−0.026 to 0.151)	0.022 (−0.071 to 0.111)	0.034 (−0.059 to 0.134)
NfL (pg/mL)	0.169** (0.112 to 0.242)	0.329** (0.267 to 0.390)	0.166** (0.109 to 0.227)	0.134** (0.074 to 0.190)
GFAP (pg/mL)	0.166** (0.104 to 0.228)	0.266** (0.201 to 0.328)	0.073* (0.007 to 0.140)	0.109** (0.049 to 0.172)
p-tau181 (pg/mL)	0.087** (0.022 to 0.152)	0.193** (0.132 to 0.256)	0.142** (0.080 to 0.205)	0.095** (0.025 to 0.161)

Abbreviations: Aβ = β-amyloid; BBM = blood biomarkers; GFAP = glial fibrillary acidic protein; GM = grey matter; MB = microbleeds; NfL = neurofilament light chain; OAβ = amyloid β oligomers; EPVS = enlarged perivascular spaces; p-tau181 = phosphorylated tau 181; TIV = total intracranial volume; WM = white matter; WMH = white matter hyperintensities.

Correlation coefficients (95% CI), *p < 0.05, **p < 0.005. OAβ, NfL, GFAP, and pTau181 log transformed.