Table 1.
Estimates of pouch use per day, cigarettes per day, and tobacco harm exposure (NNAL) over time by group (N=30)
| Outcomes, LSMa (SE) | 3mg Nicotine Group (n = 15) |
6mg Nicotine Group (n=15) |
Model | P value |
|---|---|---|---|---|
| Pouch use per day (log-transformed) | ||||
| Week 1 | 1.82 (0.16) | 1.37 (0.16) | Group: F1, 29.2=12.78 | 0.001 |
| Week 2 | 1.91 (0.16) | 1.22 (0.16) | Time: F3, 81.3=0.09 | 0.96 |
| Week 3 | 2.02 (0.16) | 1.14 (0.17) | Group x Time: F3, 81.3=1.47 | 0.23 |
| Week 4 | 1.98 (0.16) | 1.14 (0.17) | ||
| Cigarettes/day (baseline-adjusted, log-transformed) | ||||
| Week 1 | 2.09 (0.23) | 2.05 (0.19) | Group: F1, 26.2=1.29 | 0.27 |
| Week 2 | 1.66 (0.23) | 1.86 (0.19) | Time: F3, 74.4=3.77 | 0.01 |
| Week 3 | 1.52 (0.24) | 1.78 (0.19) | Group x Time: F3, 74.4=1.78 | 0.16 |
| Week 4 | 1.30 (0.25) | 1.83 (0.19) | ||
| NNAL (square-root transformed) ng/ml | ||||
| Baseline | 17.26 (1.89) | 15.98 (1.89) | Group: F1, 26.3=0.57 | 0.46 |
| Week 4 | 18.55 (1.94) | 16.04 (1.91) | Time: F1, 24.6=0.95 | 0.34 |
| Group x Time: F1, 24.7=0.80 | 0.38 |
a
LSM = least squares mean