Table 4.
Levodopa pharmacokinetic measures.
| Pharmacokinetics | Article | LD/CD means (SD) | M. pruriens mean (SD) | p value | ||||
| 11 g | 15 g | 30 g | Difference between LD/CD vs 15 g M. pruriens | Difference between LD/CD vs 30 g M. pruriens | ||||
|
| ||||||||
| AUC (ng·h/mL) | Katzenschlager et al. [31] | 16,243 (2543) | 16,306 (4024) | 43,087 (9735) | NS | 0.012 | ||
| Sakata et al. [34] | 4744 (929) | 11,186 (1528) | < 0.05 | |||||
|
| ||||||||
| C max (ng/mL) | Katzenschlager et al. [31] | 6956(1098) | 8608 (1979) | 14,606 (2662) | NS | 0.025 | ||
| Sakata et al. [34] | 3095 (700) | 7607 (1546) | < 0.05 | |||||
|
| ||||||||
| T max (min) | Katzenschlager et al. [31] | 95.5 (10.5) | 61.8 (12.9) | 72.4 (15.1) | 0.04 | NS | ||
| Sakata et al. [34] | 34.3 (4.3) | 25.7 (5.4) | 0.3 | |||||
|
| ||||||||
| T1/2 | Katzenschlager et al. [31] | 90.8 (23.8) | 58.6 (5.1) | 94.0 (25.5) | NS | NS | ||
Note: LD = levodopa, LD/CD = levodopa/carbidopa, M. pruriens = Mucuna pruriens, AUC = area under the plasma concentration curve, Cmax = the peak plasma levodopa concentration, Tmax = time to peak, Tk = apparent elimination half-time.
Abbreviation: SD = standard deviation.