Table 1. Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs).

NSAID	COX selectivity	Route of administration	Dose frequency
Aspirin	nonselective	oral	every 4 to 6 hours (when used as an anti-inflammatory)
Celecoxib	COX-2 selective	oral	1 to 2 times daily
Diclofenac	COX-2 preferential	oral, topical, rectal	2 to 3 times daily
Etoricoxib	COX-2 selective	oral	once daily
Ibuprofen	nonselective	oral, topical	every 4 to 6 hours
Indometacin	nonselective	oral, rectal	2 to 3 times daily
Ketorolac	nonselective	intramuscular, intravenous, oral	every 4 to 6 hours
Mefenamic acid	nonselective	oral	3 times daily
Meloxicam	COX-2 selective	oral	once daily
Naproxen	nonselective	oral	2 times daily
Parecoxib	COX-2 selective	intravenous, intramuscular	every 6 to 12 hours
Piroxicam	nonselective	oral	once daily