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. 2025 Jul 3;40(33):e204. doi: 10.3346/jkms.2025.40.e204

Table 1. Clinical data of autoimmune thyroiditis.

Cases 1 2 3
Disease Agammaglobulinemiaa CVID (NFkB2 def.) Di George syndrome
IUIS category 3 3 2
Sex Male Female Female
Diagnosis age of IEI 8 mon 4 yr 8 mon At birth
Current age 12 yr 11 monb 11 yr 7 mon 20 yr 9 mon
Onset age of thyroiditis 9 yr 2 mon 10 yr 5 mon 15 yr 8 mon
Clinical symptom None None Fatigue
Laboratory data
Free T4, µIU/mL (0.55–4.78) 0.84 1.4 0.83
TSH, ng/dL (0.27–4.20) 26.5 1.67 16.3
Thyroglobulin Ab, IU/mL (0–60) Positive (63.5) Negative Negative
Microsomal Ab, U/mL (0–60) Negative Positive (148.4) Positive (12,016)
TSH-receptor-Ab, IU/L (0–1.0) Negative Negative Negative
Treatment
Age at treatment initiation 9 yr 2 mon Untreated 15 yr 8 mon
Medication LT4 LT4

CVID = common variable immunodeficiencies, def. = deficiency, IUIS = the International Union of Immunological Societies, IEI = inborn errors of immunity, T4 = thyroxine, TSH = thyroid-stimulating hormone, Ab = antibody, LT4 = levothyroxine.

aNo pathogenic/likely pathogenic variant in BTK gene.

bExpired.