Table 1. Clinical data of autoimmune thyroiditis.
| Cases | 1 | 2 | 3 | |
|---|---|---|---|---|
| Disease | Agammaglobulinemiaa | CVID (NFkB2 def.) | Di George syndrome | |
| IUIS category | 3 | 3 | 2 | |
| Sex | Male | Female | Female | |
| Diagnosis age of IEI | 8 mon | 4 yr 8 mon | At birth | |
| Current age | 12 yr 11 monb | 11 yr 7 mon | 20 yr 9 mon | |
| Onset age of thyroiditis | 9 yr 2 mon | 10 yr 5 mon | 15 yr 8 mon | |
| Clinical symptom | None | None | Fatigue | |
| Laboratory data | ||||
| Free T4, µIU/mL (0.55–4.78) | 0.84 | 1.4 | 0.83 | |
| TSH, ng/dL (0.27–4.20) | 26.5 | 1.67 | 16.3 | |
| Thyroglobulin Ab, IU/mL (0–60) | Positive (63.5) | Negative | Negative | |
| Microsomal Ab, U/mL (0–60) | Negative | Positive (148.4) | Positive (12,016) | |
| TSH-receptor-Ab, IU/L (0–1.0) | Negative | Negative | Negative | |
| Treatment | ||||
| Age at treatment initiation | 9 yr 2 mon | Untreated | 15 yr 8 mon | |
| Medication | LT4 | LT4 | ||
CVID = common variable immunodeficiencies, def. = deficiency, IUIS = the International Union of Immunological Societies, IEI = inborn errors of immunity, T4 = thyroxine, TSH = thyroid-stimulating hormone, Ab = antibody, LT4 = levothyroxine.
aNo pathogenic/likely pathogenic variant in BTK gene.
bExpired.