Table 2. Clinical data of non-autoimmune hypothyroidism.

Cases		1	2	3	4	5	6	7	8	9	10	11	12
Disease		XL-agamma-globulinemia	CTLA-4 haplo-insufficiency	CVID	Hyper IgM syndrome	IPEX syndrome	Kabuki syndrome	Kabuki syndrome	Osteopetrosis	XL-SCID	Wiskott-Aldrich syndrome	Wiskott-Aldrich syndrome	Wiskott-Aldrich syndrome
IUIS category		3	4	3	1	5	2	2	9	1	2	2	2
Sex		Male	Male	Female	Male	Male	Female	Male	Female	Male	Male	Male	Male
Diagnosis age of IEI		3 yr 6 mon	74 yr 6 mon	5 yr	1 yr 9 mon	7 mon	At birth	1 yr 5 mon	2 yr 8 mon	4 mon	2 yr 6 mon	ND	3 mon
Current age		12 yr 2 mon	79 yr 3 mon	20 yr 1 mona	2 yr 3 mona	14 yr 9 mon	5 yr 8 mon	5 yr 11 mon	14 yr 6 mon	8 yr 3 mon	5 yr 8 mona	8 yr 9 mon	12 yr 5 mon
Age at HCT					2 yr				2 yr 8 mon	10 mon	3 yr 5 mon	9 mon	2 yr 5 mon
Onset age of hypothyroidism		9 yr 11 mon	65 yr	19 yr 2 mon	1 yr 9 mon	7 mon	5 mon	1 mon	8 yr 3 mon	1 yr 1 mon	4 yr 8 mon	1 mon	6 yr 4 mon
	Type	Central	ND	Central	Central	Central	Subclinical	Primary	Central	Central	Central	Subclinical	Central
Clinical symptom		NA	NA	NA	NA	NA	NA	NA	NA	NA	General weakness	NA	NA
											Cold sense
Laboratory data
	Free T4, ng/dL	0.87	ND	0.79	0.58	0.31	1.77	0.4	0.78	0.51	0.39	1.23	0.8
	TSH, µIU/mL	0.082	ND	1.02	1.94	0.8	26	388	2.7	0.103	0.39	10.2	2.92
	T3, ng/dL	83.4		22.6	59.6			78.7	93.9	25.7	29.5	166	149.8
Treatment
	Age at initiation	9 yr 11 mon	65 yr	19 yr 2 mon	1 yr 9 mon	7 mon	5 mon	1 mon	8 yr 3 mon	1 yr 1 mon	4 yr 8 mon	Untreated	6 yr 4 mon
	Medication	LT4	LT4	LT4	LT4	LT4	LT4	LT4	LT4	LT4	LT4		LT4

XL = X-linked, CTLA-4 = cytotoxic T lymphocytic antigen-4, CVID = common variable immunodeficiency, IPEX = immune dysregulation, polyendocrinopathy, enteropathy, X-linked, XL-SCID = X-linked severe combined immunodeficiency, IUIS = the International Union of Immunological Societies, IEI = inborn errors of immunity, ND = not done, HCT = hematopoietic cell transplantation, NA = not applicable, T4 = thyroxine, TSH = thyroid-stimulating hormone, T3 = triiodothyronine, LT4 = levothyroxine.

^aExpired.