Table 3. Clinical data of hypogonadism.

Cases		1	2	3	4	5	6	7	8
Disease		CHARGE syndrome	CHARGE syndrome	APDS1	CVID	XL-CGD	CTLA-4 haplo-insufficiency	LRBA def.	LRBA def.
IUIS category		2	2	3	3	5	4	4	4
Sex		Male	Female	Female	Female	Male	Female	Male	Female
Diagnosis age of IEI		12 yr 9 mon	17 yr 2 mon	11 yr	5 yr	6 yr 9 mon	14 yr4 mon	10 yr 8 mon	12 yr 9 mon
Current age		19 yr 6 mon	22 yr	18 yr 8 mon	20 yr 1 mona	23 yr	33 yr 7 mon	20 yr 10 mon	23 yr 3 mon
Age at HCT						13 yr		16 yr 7 mon
Detection age of hypogonadism		14 yr	17 yr 2 mon	16 yr 1 mon	18 yr 1 mon	15 yr 1 mon	18 yr 4 mon	15 yr 11 mon	13 yr 3 mon
Type of hypogonadism		Central	Central	Central	Central	Central	Central	Central	Central
Height at onset, cm		142.6	160	148.5	148.6	151	152.6	144	133.3
	SD	−3.8	−0.2	−2.2	−2.6	0	−1.5	−2.6	−3.5
Body weight at onset, kg		36.1	53	38.6	34.6	45.5	35	36.5	25.5
	SD	−2.4	−0.1	−2.5	−4.3	−1.5	−4.2	−2.1	−2.5
Tanner stage		I	I	II	ND	I	ND	II	I
Laboratory data
	LH, mIU/mL	0.7	0.4	0.4	0.07	1.3	1.9	1	0.4
	FSH, mIU/mL	0.6	0.1	1.1	0.43	2.2	1.2	1.5	2.4
	Testosterone, ng/mL	0.16				0.12		0.7
	Estradiol, pg/mL		29	1	74		11		1
Treatment
	Age at initiation	14 yr 6 mon	17 yr 3 mon	16 yr 3 mon	18 yr 1 mon	15 yr 8 mon	19 yr 5 mon	Untreated	15 yr 4 mon
	Bone age at initiation	12 yr	NT	13 yr 6 mon	NT	12 yr	NT		13 yr
Medication		Testosterone	Estradiol progesterone	Estradiol progesterone	Estradiol	Testosterone	Estradiol progesterone		Estradiol progesterone

APDS1 = activated phosphoinositide 3-kinase delta syndrome, CVID = common variable immunodeficiency, XL-CGD = X-linked chronic granulomatous disease, CTLA-4 = cytotoxic T-lymphocyte-associated protein 4, LRBA = lipopolysaccharide-responsive and beige-like anchor protein, def. = deficiency, IUIS = the International Union of Immunological Societies, IEI = inborn errors of immunity, HCT = hematopoietic cell transplantation, SD = standard deviation, ND = not done, LH = luteinizing hormone, FSH = follicle stimulating hormone, NT = not tested.

^aExpired.