Table 5. Clinical data of GHD.

Cases		1	2	3	4	5	6
Disease		CHARGE syndrome	CHARGE syndrome	AR-CGD	GSD	STAT3 LOF	Osteopetrosis
IUIS category		2	2	5	5	2	9
Sex		Male	Female	Female	Male	Male	Female
Current age		11 yr 2 mon	11 yr 5 mon	13 yr 8 mon	11 yr 4 mon	20 yr 1 mon	6 yr 1 mon
Age at HCT				3 yr 3 mon			10 mon
Diagnosis age of IEI		2 yr 9 mon	3 yr 1 mon	10 mon	9 mon	5 yr 1 mon	7 mon
Age at the diagnosis of GHD		8 yr 1 mon	7 yr 8 mon	4 yr 8 mon	4 yr 5 mon	9 yr	4 yr 2 mon
Parents' height
	Father/mother, cm	NA/NA	174/167	NA/NA	175/167	177/153	NA/NA
Height at diagnosis, SD		−1.4	−2.6	−2.0	−2.5	−1.6	−1.8
Body weight at diagnosis, SD		−1.5	−1.3	0.5	−0.4	−1.87	−1.3
Laboratory data at diagnosis
	IGF-1, nmol/L	41.7 (50.3–265.9)a	135.6 (102.3–460.1)a	13.9 (29.9–359.4)a	15.8 (8–250)a	86.6 (9.7–30.1)a	67.7 (29.9–359.4)a
	Insulin, µU/mL	12.3	14.15	NT	2.1	NT	NT
	Peak GH production at the provocative tests	Arginine, 2.05; L-dopa, 6.23	Glucagon, 5.36; L-dopa, 2.43	Glucagon, 6.17; L-dopa, 8.93	Glucagon, 5.83; L-dopa, 1.70	Glucagon, 2.68; L-dopa, 4.36	Arginine, 1.21; L-dopa, 1.55
Treatment		GH	GH	Untreated	GH	GH	GH
	Age at the start	8 yr 4 mon	7 yr 8 mon		4 yr5 mon	9 yr 1 mon	4 yr 2 mon
	Bone age at the start	7 yr	6 yr		3 yr 9 mon	4 yr 10 mon	3 yr
	Clinical course	−0.7 SD at 11 yr 2 mon	−1.1 SD at 11 yr 5 mon		Discontinued at 5 yr 1 mon (−2.0 SD) due to poor compliance	Discontinued at 15 yr 11 mon (−0.1 SD)	−1.1 SD at 6 yr 1 mon
	Response	Good	Good		Good	Good	Good

AR-CGD = autosomal recessive chronic granulomatous disease, GSD = glycogen storage disease, STAT3 LOF= signal transducer and activator of transcription 3 loss-of-function, IUIS = the International Union of Immunological Societies, HCT = hematopoietic cell transplantation, IEI = inborn errors of immunity, GHD = growth hormone deficiency, NA = not applicable, SD = standard deviation, IGF-1 = insulin-like growth factor-1, NT = not tested, GH = growth hormone.

^aNormal reference range may vary depending on the assay and age-specific standards.