Table 6. Clinical data of diabetes.

Cases		1	2
Disease		Ataxia telangiectasia	CTLA-4 haplo-insufficiency
IUIS category		2	4
Sex		Male	Female
Current age		25 yr 9 mon	33 yr 7 mon
Diagnosis age of IEI		13 yr	14 yr 5 mon
Onset age of diabetes		18 yr 4 mon	31 yr 8 mon
Clinical symptom		Polydipsia, polyuria	Polydipsia, polyuria
Laboratory data
	Fasting blood glucose, mg/dL (ref. 74–109)	164	125
	HbA1c, % (ref. 4.0–6.0)	7.2	8.3
	C–peptide, ng/mL (ref. 0.69–3.59)	5.53	0.86
	Insulin, µU/mL (ref. 1.0–9.6)	30.2	2.6
	Anti-GAD II Ab, U/mL (ref. 0–1.0)	Negative (0.2)	Negative (0.36)
	Anti-insulin Ab, % (ref. 0–7.0)	Negative (5.3)	Negative (4.1)
	Neuropathy	Early autonomic dysfunction	NT
	Nephropathy	No	No
	Retinopathy	No	No
Treatment
	Age at initiation	18 yr 4 mon	31 yr 8 mon
	Medication	Metformin, linagliptin, glimepiride	Subcutaneous insulin

CTLA-4 = cytotoxic T-lymphocyte-associated protein 4, IUIS = the International Union of Immunological Societies, IEI = inborn errors of immunity, ref. = reference, HbA1c = hemoglobulin A1c, GAD = glutamic acid decarboxylase, Ab = antibody, NT = not tested.