Table 3.
Univariable and multivariable logistic regression analysis for ABMR/MVI development according to non-HLA antigen localization.
| OR | p-Value | CI (95%) | |
|---|---|---|---|
| Univariable | |||
| Recipient sex (female) | 2.932 | 0.006 | 1.372–6.265 |
| Recipient age (years) | 0.993 | 0.634 | 0.966–1.021 |
| Body mass index (kg/m2) | 1.005 | 0.873 | 0.942–1.072 |
| Cause of end-stage renal disease (immune mediated) | 0.917 | 0.860 | 0.352–2.392 |
| Preemptive KT | 1.503 | 0.463 | 0.506–4.464 |
| Median time on dialysis (months) | 1.003 | 0.703 | 0.987–1.019 |
| Donor age (years) | 0.992 | 0.565 | 0.967–1.018 |
| Donor type (live donor) | 1.024 | 0.958 | 0.420–2.500 |
| Median cold ischemia time (h) | 1.016 | 0.591 | 0.959–1.076 |
| Previous transplantation | 3.186 | 0.078 | 0.878–11.563 |
| HLA cPRA over 50% before KT | 3.827 | 0.009 | 1.396–10.492 |
| Extracellular non-HLA MFI ratio sum before KT | 1.051 | 0.035 | 1.003–1.100 |
| Intracellular non-HLA MFI ratio sum before KT | 1.045 | 0.048 | 1.000–1.092 |
| A. Multivariable, non-HLA as extracellular MFI ratio sum | |||
| HLA cPRA over 50% before KT | 2.701 | 0.129 | 0.748–9.756 |
| Extracellular non-HLA MFI ratio sum before KT | 1.053 | 0.040 | 1.002–1.107 |
| Recipient sex (female) | 1.936 | 0.123 | 0.836–4.480 |
| Previous transplantation | 1.606 | 0.561 | 0.325–7.932 |
| B. Multivariable, non-HLA as intracellular MFI ratio sum | |||
| HLA cPRA over 50% before KT | 2.110 | 0.245 | 0.599–7.440 |
| Intracellular non-HLA MFI ratio sum before KT | 1.044 | 0.069 | 0.997–1.093 |
| Recipient sex (female) | 2.296 | 0.048 | 1.006–5.238 |
| Previous transplantation | 1.607 | 0.563 | 0.322–8.011 |