Table 2.
Cefiderocol MIC in E. coli keio wild-type strains as well as in ΔcirA, ΔybiX and ΔcirA/ΔybiX strains with and without the blaKPC-2 (with D179Y-D209V) or blaKPC-33 (D179Y) plasmids.
| Strains | Cefiderocol MIC (mg/L) | Fold-increase in cefiderocol MIC compared to strains without plasmid | Fold-increase in cefiderocol MIC compared to keio WT |
|---|---|---|---|
| keio WT | 0.03 | – | – |
| keio WT + blaKPC-2 (with D179Y-D209V) | 0.5 | 16 | 16 |
| keio WT + blaKPC-33 (D179Y) | 0.5 | 16 | 16 |
| keio ΔcirA | 0.12 | – | 4 |
| keio ΔcirA + blaKPC-2 (with D179Y-D209V) | 2 | 16 | 66 |
| keio ΔcirA + blaKPC-33 (D179Y) | 4 | 32 | 133 |
| keio ΔybiX | 0.03 | – | – |
| keio ΔybiX + blaKPC-2 (with D179Y-D209V) | 1 | 32 | 32 |
| keio ΔybiX + blaKPC-33 (D179Y) | 0.5 | 16 | 16 |
| keio ΔcirA/ΔybiX | 0.5 | – | 16 |
| keio ΔcirA/ΔybiX + blaKPC-2 (with D179Y-D209V) | > 32 | 64 | 1066 |
| keio ΔcirA/ΔybiX + blaKPC-33 (D179Y) | > 32 | 64 | 1066 |