Table 1.
NK cell vs ILC cell subsets.
| Identifiers | cNK | ILC1 | ILC2 | ILC3 | trNK |
|---|---|---|---|---|---|
| Transcription factors | Eomes (6, 7) T-bet (8, 9) |
Hobit (10) T-bet (9, 11) |
GATA3 (9, 12) | RORγT (9) | +/- Eomes & Tbet (13), Tcf1 (14) |
| Chemotactic and homing molecules | CCL3, CCL4, and CCL5 (15, 16) XCL1 (17, 18), XCL2 (18) |
CCL4 (19) CXCR3 and CXCR6 (20, 21), XCL1 (17), CXCL9 (22) |
CCR6 (11) | CD69 (13, 14), CCR5 (liver) (23), CXCR6 (liver but not skin) (23), | |
| Cytokines | IFNγ (24–26), TNFα (16, 24, 27), GM-CSF (16) | IFNγ (11, 28), TNFα (11) | IL-4, IL-5, IL-9, & IL-13 (12), IL-10 (29), Amphiregulin (30) |
IL-17 (31), IL-22 (31, 32), GM-CSF (33), TNFα (34), LTa & LTb (34, 35), BAFF (36) |
IFNγ (murine) (13, 14), TNFα & GM-CSF (13) |
| Other Effectors | CD16→ADCC (3) Granzyme/perforin (37) TRAIL/FASL (38–40) |
Granzyme (10, 19) TRAIL (41, 42) |
PGD2 (43) | RANKL (36, 44) | TRAIL (45) |