Table 3.
NK cell homing in cutaneous disease.
| Addressins/pathways | |
|---|---|
| Infection | |
| Dengue virus | - CLA, CCR5, CXCR6 up-regulation [130 – human] |
| Leishmaniasis | - CCR10 (KO improves skin disease) [119 – mice] |
| Vaccinia virus | - Low CLA expression [131 – human] |
| Cytomegalovirus | - EOMES+ and acquire CD69 [43 – mice] |
| - TRAIL-dependent [19 – mice] | |
| Inflammatory/Autoimmune | |
| Atopic Dermatitis | - CLA+ [125 – human] |
| - IL-15 KO increases ILC2 cells & correlates with worse eczema [133 – mice] | |
| - IL-17 inhibits trNK cell function in mouse eczema herpeticum model & worsens skin disease [132-133 – mice] | |
| Psoriasis | CXCR3, CCR5, - diminished CLA expression [118 – human] |
| Allergic contact dermatitis | - CCL27-CCR10 axis [123,135 – mice] |
| - CXCR3+CCR6+CCR5+ [136 – human] | |
| Hidradenitis suppurativa | - CD38 [137 – human] |
| Cutaneous malignancy | |
| nasal type NK cell lymphoma | - CLA+ [138 – human] |
| Melanoma | - TIM3 expression [139 – human] |
| - Decreased ICAM1 & E-selectin [140 – human] | |
| Squamous cell carcinoma | - TGFβ signaling [141-142 – human] |
| - Decreased E-selectin [143 – human] | |