Table 2.

Gastrointestinal diseases requiring differentiation from pediatric inflammatory bowel disease

Infectious enteritis  Viral enteritis (including cytomegalovirus), bacterial enteritis (Salmonella, Campylobacter, Yersinia, and others), intestinal tuberculosis, Clostridioides difficile

Eosinophilic gastrointestinal diseases

Vascular lesions  IgA vasculitis, ANCA-associated vasculitis, Takayasu’s disease, intestinal Behçet’s disease, ischemic enteritis

Primary immunodeficiency  Chronic granulomatosis, interleukin-10 receptor deficiency, A20 haploinsufficiency, X-linked lymphoproliferative syndrome type 2, Wiskott-Aldrich syndrome, IPEX syndrome, and others

SLCO2A1-associated small bowel disease (chronic enteropathy associated with the SLCO2A1 gene)

Celiac disease

Drug-induced enteritis  Induced by nonsteroidal anti-inflammatory drugs and others

ANCA anti-neutrophilic cytoplasmic autoantibody, Ig immunoglobulin A, IL interleukin, IPEX immunodysregulation, polyendocrinopathy, enteropathy, X-linked