Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Aug 12;12:1506501. doi: 10.3389/fcvm.2025.1506501

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2025 Sun, Zhang, Li, Zhang, Guo, Chen, Wei, Lin and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Diagram depicting the cellular pathways involved in myocardial infarction. It shows decreased oxygen and nutrients leading to mitochondrial dysfunction, Ca²+ overload, and ROS production, causing cell death. Inflammatory factors lead to macrophage recruitment, fibroblast differentiation, fibrosis, re-entry, and arrhythmia. Pathways involve glycolysis, MCU, mPTP opening, RYR2 hyperactivation, and NF-κB activation. Nav1.5 channel decrease and NCX activity are also illustrated. — Mitochondrial function and the mechanism of ischemic arrhythmia.