Table 2.

Regulation of tumor immunity by TAMs and colon cancer cell-derived exosomes.

Exosomes type	Cargos	Name	Mechanism	Biological function	Ref.
Tumor cells–derived	miRNA	miR-1246	↑ TGF-β, IL-10, MMP	promote M2 polarization, EMT, tumorgenesis	(136)
			↑ β-catenin, IL-6, p-STAT3, TGF-β1	promote M2 polarization	(137)
	miRNA	miR-92a-3p	↑ p-ERK, TGF-β, VEGFA, ↓ TNF-α	promote M2 polarization, tumor cell invasion, migration, angiogenesis	(138)
	circRNA	circ_0020095	↑ IGF2BP1, ↓ IRAK1	inhibit M1 polarization, promote tumor cell proliferation, invasion, migration	(139)
	lncRNA	lncXIST	↓ miR-17-5p,↑ PDGFRA, ↑ p-AKT, p-ERK, p-STAT3, p-STAT6	promote M2 polarization, tumor cell proliferation, invasion, migration	(140)
	protein	HSP90B1	↓ TNF-α, IL-6, IL-12, ↑ IL-10, TGF-β, CCL-1	promote M2 polarization, inhibit CD8+ T cell viability, promote liver metastasis	(141)
	protein	HSP70	↓ IL-10, ↑ TNF-α, IFN-γ	promote immune response, CD8+ T cell infiltration	(142)
TAMs-derived	miRNA	miR-21-5p	↓ BRG1	promote tumor cell invasion, migration	(143)
	miRNA	miR-155-5p	↓ BRG1	promote tumor cell invasion, migration	(143)
			↑ IL-6, ↓ ZC3H12B	promote tumor cell proliferation, anti-apoptosis, immune escape, inhibit CD3+ T cell proliferation	(144)
	miRNA	miR-183-5p	↓ THEM4, ↑ p-AKT, p-NF-κB	promote tumor cell proliferation, invasion, migration, anti-apoptosis	(145)
	miRNA	miR-186-5p	↓ DLC1, ↑ β-catenin	promote tumor cell proliferation, invasion, migration, EMT	(146)
	miRNA	miR-501-3p	↓ SETD7, ↑ DNMT1, ↓ SOCS3	promote tumor cell invasion, migration	(147)
	protein	FTH1	/	promote tumor cell proliferation	(148)