Table 1.

Baseline and Clinical Characteristics of Offspring of Parents With Exceptional Longevity Versus Offspring of Parents With Usual Survival (N = 139)

	OPEL (n = 84)	OPUS (n = 55)	p Value
Demographics Age* (years)	77.7 (72.8–83.0)	80.1 (78.4–83.8)	0.009
Sex, n (%)   Female	49 (58.33)	29 (52.73)	0.52
Years of education*	18 (16.5–20)	18 (16–20)	0.22
eTIV* (mm3)	1 437 992 (1 266 470–1 541 138)	1 396 298 (1 269 035–1 525 339)	0.49
White matter hypointensities* (mm3)	2 262.85 (1 514.75–3 904.8)	2 279.6 (1 553.4–3 387.9)	0.81
Global health score*,†,‡ (range 1–8)   Arthritis, n (%)   Chronic heart failure, n (%)   COPD, n (%)   Depression, n (%)   Diabetes, n (%)   Hypertension, n (%)   Myocardial infarction, n (%)   Stroke, n (%)	1 (0–1) 32 (38.55) 0 (0) 1 (1.20) 7 (8.33) 6 (7.14) 28 (35.00) 6 (7.14) 0 (0)	1 (0–2) 10 (18.51) 1 (1.81) 0 (0) 3 (5.56) 2 (3.64) 23 (41.82) 3 (5.45) 0 (0)	0.45 0.02 0.39 1.00 0.74 0.48 0.51 1.00 N/A
Cognitive tests * , § Global Cognition Digit Symbol Substitution Trail Making Test (B-A) Free Recall Boston Naming Trail Making Test—A Digit Span	2.54 (−0.84 to 7.82) 64 (53–75) 36 (26–57) 36 (32–39) 56 (52–60) 35 (28–49) 18 (15–20)	2.11 (0.29–5.95) 62 (53–71) 36.5 (21–72) 35 (31–38) 56 (56–60) 38.5 (32–45) 17 (14–21)	0.97 0.60 0.90 0.46 0.83 0.40 0.55

Notes: eTIV = estimated total intracranial volume; N/A = not applicable; OPEL = offspring of parents with exceptional longevity (at least 1 parent reached the age of 95 or beyond); OPUS = offspring of parents with usual survival (neither parent reached the age of 95 or beyond).

^*Median (IQR) reported.

^†Global Health Score is obtained from the dichotomous ratings of the presence or absence of diabetes, chronic heart failure, arthritis, hypertension, depression, stroke, chronic obstructive pulmonary disease, angina and myocardial infarction.

^‡Total participants with global health score values, N = 132.

^§Total Participants with cognitive assessments, N = 119 except for global cognition where N = 101 and language where N = 117.