Table 2.
Gray Matter Covariance Network Associated With Parental Longevity Status After Adjusting for Age, Sex, Years of Education, Estimated Total Intracranial Volume, and White Matter Hypointensities
| Peak structure | X | Y | Z | K |
|---|---|---|---|---|
| Negative (less volume in OPEL) | ||||
| Supplementary motor area, R | 1.7 | 16.1 | 67.6 | 13 259 |
| Precuneus, R | 1.7 | −71.7 | 58.0 | 2 637 |
| Postcentral gyrus, R | 29.7 | −46.6 | 71.3 | 444 |
| Cerebellum (VIII), R | 35.6 | −37.8 | −41.5 | 54 444 |
| Middle frontal gyrus, R | 29.7 | 19.8 | 60.2 | 561 |
| Middle frontal gyrus, L | −38.9 | 52.2 | 23.4 | 249 |
| Precentral gyrus, R | 23.8 | −23.7 | 75.0 | 581 |
| Inferior parietal gyrus, L | −50.7 | −42.2 | 55.1 | 324 |
| Inferior frontal gyrus, opercular, L | −53.6 | 22.0 | 33.0 | 222 |
| Middle occipital lobe, L | −40.4 | −83.5 | 34.4 | 495 |
| Postcentral gyrus, R | 44.4 | −38.5 | 62.5 | 332 |
| Middle frontal gyrus, orbital, L | −46.3 | 53.7 | −3.2 | 162 |
| Precentral gyrus, L | −35.9 | 2.1 | 63.9 | 513 |
| Middle frontal gyrus, R | 50.3 | 43.4 | 20.4 | 949 |
| Superior frontal gyrus, R | 22.3 | 69.9 | 7.1 | 405 |
| Middle frontal gyrus, orbital, R | 47.4 | 53.7 | −3.2 | 181 |
| Pallidum, L | −18.2 | 2.1 | 6.4 | 126 |
| Postcentral gyrus, L | −50.0 | −9.0 | 55.1 | 111 |
| Cuneus, L | −12.3 | −84.2 | 18.2 | 123 |
| Inferior occipital lobe, R | 34.1 | −96.0 | −8.3 | 65 |
| Middle frontal gyrus, L | −31.5 | 63.3 | 8.6 | 158 |
| Inferior frontal gyrus, triangular, L | −53.6 | 36.0 | 14.5 | 51 |
| Superior frontal gyrus, L | −21.9 | 64.0 | 21.9 | 58 |
| Superior frontal gyrus, L | −11.6 | 13.1 | 52.9 | 469 |
| Postcentral gyrus, R | 64.4 | −16.4 | 41.8 | 94 |
| Postcentral gyrus, L | −31.5 | −40.7 | 69.8 | 528 |
| Superior frontal gyrus, R | 17.9 | 67.0 | 21.2 | 77 |
| Precuneus, L | −11.6 | −49.6 | 51.4 | 322 |
| Middle frontal gyrus, L | −29.3 | 32.3 | 52.1 | 54 |
| Middle frontal gyrus, R | 31.9 | 16.8 | 38.1 | 54 |
| Fusiform gyrus, R | 35.6 | −54.0 | −7.6 | 181 |
| Inferior temporal gyrus, R | 51.1 | −16.4 | −20.9 | 91 |
| Putamen, R | 21.6 | 2.1 | 11.6 | 97 |
| Precuneus, R | 14.9 | −56.2 | 43.3 | 76 |
| Cingulate gyrus, posterior, R | 12.0 | −40.7 | 30.0 | 115 |
| Middle frontal gyrus, L | −30.0 | 15.3 | 62.5 | 55 |
| Fusiform gyrus, L | −33.0 | −62.8 | −6.1 | 74 |
| Positive (more volume in OPEL) | ||||
| Rectus, R | 10.5 | 20.5 | −20.9 | 61 323 |
| Insula, L | −31.5 | 24.2 | 2.7 | 20 286 |
| Middle frontal gyrus, R | 26.7 | 54.4 | 2.7 | 2 305 |
| Rolandic operculum, R | 40.8 | −20.8 | 18.9 | 22 949 |
| Inferior frontal gyrus, triangular, L | −40.4 | 43.4 | 8.6 | 5 000 |
| Inferior frontal gyrus, triangular, R | 42.2 | 31.6 | 18.2 | 1 582 |
| Middle frontal gyrus, orbital, L | −30.0 | 38.9 | −12.0 | 501 |
| Precuneus, R | 20.8 | −59.9 | 22.6 | 2 730 |
| Middle temporal gyrus, L | −52.9 | −43.7 | 6.4 | 6 562 |
| Cingulate gyrus, posterior, L | 0.2 | −34.8 | 31.5 | 839 |
| Lingual gyrus, L | −8.7 | −65.8 | 6.4 | 3 121 |
| Fusiform gyrus, L | −46.3 | −52.5 | −17.9 | 258 |
| Inferior temporal gyrus, R | 46.7 | −46.6 | −16.5 | 154 |
| Inferior frontal gyrus, orbital, R | 26.7 | 36.0 | −16.5 | 429 |
| Lingual gyrus, R | 18.6 | −68.7 | −9.1 | 466 |
| Fusiform gyrus, R | 39.3 | −67.3 | −19.4 | 602 |
| Cerebellum (IV-V) | 22.3 | −39.2 | −17.9 | 233 |
| Postcentral gyrus, R | 55.5 | −3.1 | 27.1 | 318 |
| Lingual gyrus, R | 7.6 | −88.6 | −9.1 | 102 |
| Temporal pole, superior, R | 44.4 | 18.3 | −22.4 | 123 |
| Cerebellum (Crus I), L | −22.7 | −87.2 | −22.4 | 517 |
| Fusiform gyrus, L | −24.1 | −68.0 | −12.0 | 95 |
| Lingual gyrus, L | −9.4 | −74.6 | −9.1 | 87 |
| Calcarine, L | −2.8 | −91.6 | −10.6 | 223 |
Notes: Peak structure is the brain region where most of the cluster is located; XYZ coordinates are peak structure coordinates; L = left; R = right; Threshold z = ± 1.96, k >50.