Table 4. Pharmacokinetic data of three compounds in rats.

Parameter	w11		w12		w18
	PO	IV	PO	IV	PO	IV
	5 mg kg−1	1 mg kg−1	5 mg kg−1	1 mg kg−1	5 mg kg−1	1 mg kg−1
AUClast (ng h mL−1)	20 700	3530	14 300	2770	20 300	4640
C max (ng mL−1)	4800	5180	5230	5570	5700	6200
CL (mL h−1 kg−1)	NA	0.281	NA	0.377	NA	0.214
T 1/2 (h)	3.1	1.0	0.55	0.7	3.0	1.2
F (%)	117.5		103.2		103.2