FIGURE 3.

Boxplots of metabolite concentrations for “T2-high (n=161)” versus “T2-low (n=83)” participants, irrespective of symptom burden. Samples taken from scheduled study visits. a) Boxplot of LTE₄ concentration in “T2-high (n=161)” versus “T2-low (n=83)” participants. b) Boxplot of 2,3-dinor-11β-PGF_2α concentration in “T2-high (n=161)” and “T2-low (n=83)” participants. T2-high: fractional exhaled nitric oxide ≥20 ppb and blood eosinophil count ≥0.15×10⁹ cells·L⁻¹; T2-low: fractional exhaled nitric oxide <20 ppb and blood eosinophil count <0.15×10⁹ cells·L⁻¹; LTE₄: leukotriene-E₄. Outlying values were excluded if they were more than 1.5 times the IQR below the first quartile (Q1) or more than 1.5 times the IQR above the third quartile (Q3).