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. 2025 Aug 12;16:1636035. doi: 10.3389/fmicb.2025.1636035

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Copyright © 2025 Song, Cheng, Dong, Li, Cheng, Shang, Li, Zhu, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of PB28 dihydrochloride and three dose-response curves. Panel A shows a chemical structure labeled "PB28 dihydrochloride." Panel B depicts a green curve for Vero E6 cell viability with a CC50 of 50.64 micromolar. Panel C presents a blue curve for ST cell viability with a CC50 of 38.79 micromolar. Panel D illustrates a dark blue curve for HCT-8 cell viability with a CC50 of 63.35 micromolar. — (A) Chemical structure of PB28 dihydrochloride. (B–D) PB28 effects on cell viability following 48-h exposure in Vero E6 (B), ST (C), and HCT-8 (D) cell lines (n = 3).