Skip to main content
. 2025 Apr 28;16(4):1389–1402. doi: 10.1007/s41999-025-01201-3

Table 4.

Association between STOPP/START and healthcare utilization outcomes using negative binomial regression (incident rate ratios (IRR), 95% confidence intervals (CIs))

M (SD)a GP visits (n = 2487)
Adjusted IRR (95% CI)b
Model 1c Model 2d
Any STOPPe (n = 909) 4.98 (4.79) 1.06 (1.00, 1.13), p = 0.051
 Number of STOPP PIMS
0 STOPP (n = 2082) 3.83 (3.33) (Referent)
1 STOPP (n = 658) 4.69 (4.28) 1.05 (1.00, 1.13), p = 0.064
≥ 2 STOPP (n = 251) 5.72 (5.87) 1.06 (0.96, 1.17), p = 0.267
Any STARTe (n = 1062) 2.09 (6.77) 1.07 (1.01, 1.13), p = 0.018f
 Number of START PPOs
0 START (n = 1933) 3.89 (3.57) (Referent)
1 START (n = 651) 4.39 (3.49) 1.07 (1.00, 1.15), p = 0.038
≥ 2 START (n = 407) 5.19 (5.35) 1.07 (0.99, 1.16), p = 0.097
M (SD)a ED visit (n = 2500)
Adjusted IRR (95% CI)b
Model 1c Model 2d
Any STOPPe (n = 915) 0.37 (0.85) 0.91 (0.74, 1.11), p = 0.335
Number of STOPP PIMS
0 STOPP (n = 2091) 0.27 (0.69) (Referent)
1 STOPP (n = 662) 0.33 (0.81) 0.88 (0.71, 1.10), p = 0.260
 ≥ 2 STOPP (n = 253) 0.46 (0.93) 0.97 (0.72, 1.31), p = 0.847
Any STARTe (n = 1066) 0.39 (0.80) 1.23 (1.03, 1.48), p = 0.025
Number of START PPOs
0 START (n = 1940) 0.22 (0.70) (Referent)
1 START (n = 653) 0.36 (0.74) 1.20 (0.97, 1.49), p = 0.089
 ≥ 2 START (n = 413) 0.43 (0.87) 1.28 (1.00, 1.63), p = 0.050
M (SD)a Outpatient visit (n = 2493)
Adjusted IRR (95% CI)b
Model 1c Model 2d
Any STOPPe (n = 914) 2.34 (8.50) 1.09 (0.92, 1.29), p = 0.304
 Number of STOPP PIMS
0 STOPP (n = 2085) 1.58 (5.30) (Referent)
1 STOPP (n = 660) 2.21 (6.14) 1.08 (0.90, 1.30), p = 0.381
≥ 2 STOPP (n = 254) 2.67 (12.74) 1.11 (0.84, 1.46), p = 0.452
Any STARTe (n = 1062) 2.09 (6.77) 1.21 (1.02, 1.42), p = 0.024
 Number of START PPOs
0 START (n = 1937) 1.66 (6.27) (Referent)
1 START (n = 650) 2.11 (8.07) 1.26 (1.04, 1.52), p = 0.018
≥ 2 START (n = 412) 2.06 (3.93) 1.13 (0.91, 1.41), p = 0.271
M (SD)a Hospital admission (n = 2501)
Adjusted IRR (95% CI)b
Model 1c Model 2d
Any STOPPe (n = 916) 0.49 (1.79) 1.38 (1.08, 1.75), p = 0.009
 Number of STOPP PIMS
0 STOPP (n = 2091) 0.28 (1.03) (Referent)
1 STOPP (n = 662) 0.46 (1.92) 1.28 (0.99, 1.66), p = 0.062
≥ 2 STOPP (n = 254) 0.59 (1.40) 1.70 (1.17, 2.47), p = 0.006
Any STARTe (n = 1066) 0.44 (1.55) 1.24 (0.99, 1.54), p = 0.063
Number of START PPOs
0 START (n = 1941) 0.29 (1.16) (Referent)
1 START (n = 653) 0.40 (1.66) 1.21 (0.93, 1.57), p = 0.158
≥ 2 START (n = 413) 0.52 (1.37) 1.28 (0.95, 1.73), p = 0.108

aMean and standard deviation of healthcare utilisation variables at Wave 5

bAdjusted for age group, sex, education, employment status, insurance coverage, multimorbidity, polypharmacy, and wave 4 healthcare utilisation

cModel 1: PIP exposure assessed using binary variables for presence or absence of STOPP/START

dModel 2: PIP exposure assessed using categorical variables for presence of 0, 1 and ≥ 2 STOPP/START criteria

eReferent: none

fAssociations with p <0.05 are in bold