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. 2025 Aug 12;16:1630311. doi: 10.3389/fimmu.2025.1630311

Figure 3.

A composite image with multiple panels illustrating research data on KCTD10 and β-catenin expression in lung cancer. Panel A shows a Western blot for protein markers. Panel B presents a bar graph of peptide scores for various proteins. Panel C is a box plot comparing β-catenin expression in lung tumor versus normal tissue. Panel D includes immunohistochemistry images showing β-catenin expression across lung cancer grades. Panels E and F present bar graphs of β-catenin IHC scores for lung cancer and LUAD. Panel G shows a scatter plot illustrating the correlation between KCTD10 and β-catenin expression. Panels H-K are Kaplan-Meier survival curves for lung cancer outcomes, and Panel L is a Western blot analyzing protein expression in A549 cells.

Interaction between KCTD10 and β-catenin proteins. (A) IP-MS and silver staining showing differential bands between anti-KCTD10 antibodies and IgG. (B) The top nine polypeptide scores of KCTD10-interacting proteins. (C) GEPIA database analysis of β-catenin expression in normal and lung cancer tissues. (D, E) IHC analysis of β-catenin expression and corresponding staining scores in different lung cancer grades (n=80). (F) IHC analysis of β-catenin in LUAD (n=42). (G) Correlation between KCTD10 and β-catenin expression in lung cancer. (H–K) Correlation between β-catenin expression and overall/post-progression survival of lung cancer patients. (H) HR=1.15 (1.02-1.29), logrank P=0.027. (I) HR=1.45 (1.08-1.97), logrank P=0.014. (J) HR=1.72(1.31-2.25), logrank P=6.3e-05. (K) HR=1.98 (1.29-3.05), logrank P=0.0015. (L) Western blot analysis of β-catenin expression and its downstream genes in A549 cells. *P < 0.05, **P < 0.01, ***P < 0.001.