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. 2025 Aug 12;16:1630311. doi: 10.3389/fimmu.2025.1630311

Figure 7.

Diagrams and graphs show experimental results on Kctd10 gene in cancer studies. Panel A illustrates gene structure. Panel B outlines experimental procedure with tamoxifen treatment and LLC cell injection. Panel C compares liver nodules between Kctd10 mutant and control mice with a bar graph showing increased nodules in mutants. Panel D shows histological sections and a bar graph indicating more cancer area in mutants. Panel E features immunofluorescent staining for proteins with bar graphs showing expression differences. Panel F displays tissue staining for markers with bar graphs showing significant differences in protein expression levels.

Endothelial Kctd10 knockout inhibits angiogenesis and metastatic phenotypes in lung tumors. (A) Construction strategy for Kctd10flox/floxCDH5CreERT2/+ mice. (B) Experimental strategy for inducible Kctd10 knockout and LLC cell injection in Kctd10flox/floxCDH5CreERT2/+ mice. Mice were treated by tamoxifen (75 mg/kg) for one week (n=5/group). (C, D) Images of lung cancer and corresponding HE staining in conditional knockout mice. (E, F) Immunofluorescence and IHC analysis of target gene expression in mouse lungs and lung tumor tissues. ***P < 0.001.