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. 2025 May 2;29(8):2588–2609. doi: 10.1007/s10461-025-04719-6

Table 5.

Socio-demographic characteristics at different follow-up times by PrEP initiation, KwaZulu Natal, August 2021 to July 2022

1-month follow-up
Variable Total (N1 = 190) On PrEP (N2 = 148) Off PrEP (N3 = 42)
Demographic variables n % (95% CI) n % (95% CI) n % (95% CI) F-value p-value
Ethnicity
N1 = 189; N2 = 148; N3 = 41
Black African 187 98.4 (93.7–99.8) 148 100 39 95.1 (79.9–99.9) 9.2 0.02
Coloured 1 0.5 (0.1–3.2) 0 0 1 2.4 (0.5–10.6)
 Other 1 0.5 (0.1–3.2) 0 0 1 2.4 (0.5–10.6)
Sex
Male 37 19.5 (9.5–35.8) 30 20.3 (9.6–37.9) 7 16.7 (6.9–35.0) 0.5 0.48
Female 153 80.5 (64.2–90.5) 118 79.7 (62.1–90.4) 35 83.3 (65.0–93.1)
Age categories
15–19 years 130 68.4 (46.7–84.3) 109 73.7 (57.8–85.1) 21 50.0 (9.2–90.8) 1.3 0.30
20–24 years 57 30.0 (14.9–51.3) 36 24.3 (13.4–40.0) 21 50.0 (9.2–90.8)
25–29 years 2 1.1 (0.2–5.3) 2 1.4 (0.3–6.8) 0 0
30–35 years 1 0.5 (0.0–6.0) 1 0.7 (0.1–7.2) 0 0
Highest education attained
N1 = 189; N2 = 148; N3 = 41;
Primary education 1 0.5 (0.1–4.6) 0 0 1 2.4 (0.3–15.9) 5.3 0.05
High school education 18 99.5 (95.4–99.9) 148 100 40 97.6 (84.1–99.7)
Tertiary
Prefer not to answer
Marital status
Married (living together) 1 0.5 (0.0–6.0) 1 0.7 (0.1–7.2) 0 0 0.8 0.47
Married (living separately) 1 0.5 (0.0–6.0) 1 0.7 (0.1–7.2) 0 0
Cohabiting 3 1.6 (0.3–8.5) 1 0.7 (0.1–7.2) 2 4.8 (0.4–40.2)
Dating (living separately) 107 56.3 (49.1–63.3) 82 55.4 (50.1–60.6) 25 59.5 (34.4–80.5)
Single 77 40.5 (30.4–51.6) 62 41.9 (33.8–50.4) 15 35.7 (15.8–62.2)
Prefer not to answer 1 0.5 (0.0–6.0) 1 0.7 (0.0–10.6) 0 0
Food insecurity
Low 164 86.3 (84.8–87.7) 128 86.5 (85.3–87.6) 36 85.7 (77.4–91.3) 0.9 0.41
Medium 16 8.4 (5.9–11.9) 12 8.1 (5.4–12.0) 4 9.5 (3.8–21.8)
High 2 1.1 (0.3–3.6) 1 0.7 (0.1–6.3) 1 2.4 (0.5–10.7)
Prefer not to answer 8 4.2 (2.1–8.2) 7 4.7 (2.5–8.7) 1 2.4 (0.5–10.7)
Household income
R0–999 152 80.0 (73.9–85.0) 118 79.7 (73.8–84.6) 34 81.0 (59.1–92.6) 0.7 0.54
R1000–4999 10 5.3 (3.8–7.3) 6 4.1 (2.4–6.8) 4 9.5 (3.2–25.0)
R5000+ 1 0.5 (0.0–6.0) 1 0.7 (0.1–7.2) 0 0
Don’t know 20 10.5 (8.4–13.1) 17 11.5 (10.1–13.0) 3 7.1 (1.4–29.0)
Prefer not to answer 7 3.7 (1.5–8.5) 6 4.1 (1.9–8.3) 1 2.4 (0.2–25.6)
Received child grant
No 42 22.1 (15.3–30.9) 33 22.3 (14.5–32.8) 9 21.4 (13.4–32.4) 2.9 0.13
Yes 135 71.1 (60.4–79.8) 102 68.9 (55.8–79.6) 33 78.6 (67.6–86.6)
Don’t know 13 6.8 (4.4–10.4) 13 8.8 (5.8–13.1) 0 0
Received disability grant
N1 = 180; N2 = 138; N3 = 42;
No 161 89.4 (83.2–93.6) 123 89.1 (77.8–95.1) 38 90.5 (77.8–96.3) 0.0 0.84
Yes 19 10.6 (6.4–16.8) 15 10.9 (4.9–22.2) 4 9.5 (3.7–22.2)
Received social grant
N1 = 189; N2 = 148; N3 = 41
No 89 47.1 (37.6–56.8) 69 46.6 (34.9–58.7) 20 48.8 (37.6–60.1) 0.5 0.69
Yes 84 44.4 (36.0–53.2) 65 43.9 (34.8–53.4) 19 46.3 (32.6–60.7)
Don’t know 15 7.9 (3.9–15.4) 13 8.8 (4.3–17.2) 2 4.9 (1.2–17.7)
Prefer not to answer 1 0.5 (0.0–6.8) 1 0.7 (0.1–8.0) 0 0
Service Delivery point
Clinics 17 8.9 (2.2–29.6) 10 6.8 (1.4–27.6) 7 16.7 (3.2–54.5) 1.9 0.18
Youth Zones 29 15.3 (2.9–52.1) 18 12.2 (3.3–35.7) 11 26.2 (2.3–84.2)
High Schools 128 67.4 (36.9–87.9) 109 73.7 (48.3–89.3) 19 45.2 (6.8–90.3)
TVET colleges 16 8.4 (1.8–32.0) 11 7.4 (1.1–37.4) 5 11.9 (3.2–35.3)
3-month follow-up
Variable Total (N4 = 190) On PrEP (N5 = 148) Off PrEP (N6 = 42)
Demographic variables n % (95% CI) n % (95% CI) n % (95% CI) F-value p-value
Ethnicity
Black African 189 99.5 (96.4–99.9) 150 100 39 97.5 (78.8–99.8) 3.3 0.10
Coloured 1 0.5 (0.1–3.6) 0 0 1
Other 
Sex
Male 34 17.9 (8.8–32.9) 28 18.7 (9.0–34.7) 6 15.0 (7.5–27.7) 1.0 0.35
Female 156 82.1 (67.1–91.2) 122 81.3 (65.3–91.0) 34 85.0 (72.3–92.5)
Age categories
15–19 years 129 67.9 (55.2–78.4) 103 68.7 (54.7–79.9) 26 65.0 (47.6–79.2) 0.5 0.63
20–24 years 57 30.0 (18.6–44.5) 43 28.7 (16.6–44.8) 14 35.0 (20.8–52.4)
25–29 years 2 1.1 (0.2–5.3) 2 1.3 (0.3–6.8) 0 0
30–35 years 2 1.1 (0.2–5.3) 2 1.3 (0.3–6.8) 0 0
Highest education attained
N4 = 189; N5 = 148; N6 = 41
Primary education
High school education 185 97.9 (92.9–99.4) 145 97.3 (91.2–99.2) 40 100 0.6 0.52
Tertiary 3 1.6 (0.5–5.1) 3 2.0 (0.6–6.4) 0 0
Prefer not to answer 1 0.5 (0.1–4.8) 1 0.7 (0.1–5.8) 0 0
Marital status
Married (living together)
Married (living separately) 1 0.5 (0.1–5.2) 1 0.7 (0.1–6.6) 0 0 0.3 0.83
Cohabiting 1 0.5 (0.1–5.2) 1 0.7 (0.1–6.6) 0 0
Dating (living separately) 115 60.5 (54.8–66.0) 89 59.3 (53.2–65.2) 26 65.0 (48.0–78.9)
Single 70 36.8 (30.2–44.1) 56 37.3 (29.3–46.2) 14 35.0 (21.1–52.0)
Prefer not to answer 3 1.6 (0.3–7.2) 3 2.0 (0.4–9.4) 0 0
Food insecurity
Low 168 88.4 (85.3–91.0) 133 88.7 (84.3–91.9) 35 87.5 (64.9–96.4) 0.3 0.76
Medium 15 7.9 (5.3–11.6) 12 8.0 (5.4–11.7) 3 7.5 (1.9–25.8)
High 2 1.1 (0.2–4.8) 1 0.7 (0.1–5.8) 1 2.5 (0.3–20.3)
Prefer not to answer 5 2.6 (1.5–4.6) 4 2.7 (1.2–5.9) 1 2.5 (0.3–20.3)
Household income
R0–999 154 81.1 (74.1–86.5) 120 80.0 (74.1–84.8) 34 85.0 (68.9–93.5) 0.4 0.77
R1000–4999 12 6.3 (3.7–10.5) 9 6.0 (3.9–9.1) 3 7.5 (2.8–18.4)
R5000+ 1 0.5 (0.1–5.2) 1 0.7 (0.1–6.6) 0 0
Don’t know 15 7.9 (5.1–12.0) 13 8.7 (6.1–12.1) 2 5.0 (1.0–21.7)
Prefer not to answer 8 4.2 (1.8–9.4) 7 4.7 (1.7–12.0) 1 2.5 (0.2–21.2)
Received child grant
No 40 21.1 (17.0–25.8) 30 20.0 (15.7–25.1) 10 25.0 (10.9–47.6) 2.3 0.16
Yes 138 72.6 (66.5–78.1) 108 72.0 (66.2–77.2) 30 75.0 (52.4–89.1)
Don’t know 12 6.3 (4.5–8.7) 12 8.0 (6.2–10.3) 0 0
Received disability grant
N4 = 183; N5 = 143; N6 = 40
No 155 84.7 (77.0–90.1) 125 87.4 (76.0–93.8) 30 75.0 (55.9–87.7) 2.2 0.17
Yes 28 15.3 (9.9–23.0) 18 12.6 (6.2–24.0) 10 25.0 (12.4–44.1)
Received social grant
No 94 49.5 (367–62.3) 75 50.0 (36.8–63.3) 19 47.5 (32.2–63.2) 4.3 0.03
Yes 85 44.7 (36.4–53.4) 64 42.7 (34.9–50.8) 21
Don’t know 11 5.8 (2.2–14.3) 11 7.3 (3.1–16.5) 0 52.5 (36.8–67.8)
Prefer not to answer 0
Service Delivery point
Clinics 29 15.3 (7.0–30.2) 22 14.7 (5.6–33.1) 7 17.5 (5.6–42.9) 4.4 0.04
Youth Zones 31 16.3 (7.4–32.1) 18 12.0 (5.2–25.2) 13 32.5 (15.8–55.2)
High Schools 115 60.5 (42.3–76.3) 99 66.0 (45.6–81.8) 16 40.0 (26.4–55.3)
TVET colleges 15 7.9 (2.0–26.1) 11 7.3 (1.7–26.5) 4 10.0 (3.2–26.9)
6–month follow–up
Variable Total (N7 = 182) On PrEP (N8 = 155) Off PrEP (N9 = 27)
Demographic variables n % (95% CI) n % (95% CI) n % (95% CI) F-value p-value
Ethnicity
Black African 180 99.5 (96.4–99.9) 154 99.4 (96.4–99.9) 26 96.3 (81.0–99.9) 0.17 0.86
Coloured 1 0.5 (0.1–3.7) 1 0.6 (0.1–3.6) 0 0
Other  0.5 (0.1–3.7) 3.7 (0.1–19.0)
Sex
Male 30 16.5 (11.4–22.7) 28 18.1 (12.4–25.0) 2 7.4 (0.9–24.3) 1.9 0.17
Female 152 83.5 (77.3–88.6) 127 81.9 (75.0–87.6) 25 92.6 (75.7–99.1)
Age categories
15–19 years 106 58.2 (50.7–65.5) 92 59.4 (51.2–67.2) 14 51.9 (31.9–71.3) 1.2 0.72
20–24 years 68 37.4 (30.3–44.8) 56 36.1 (28.6–44.2) 12 44.4 (25.5–64.7)
25–29 years 5 2.8 (0.1–6.3) 4 2.6 (0.7–6.5) 1 3.7 (0.1–19.0)
30–35 years 3 1.7 (0.3–4.7) 3 1.9 (0.4–5.6) 0 0
Highest education attained
Primary education
High school education 174 95.6 (91.5–98.1) 147 94.8 (90.1–97.7) 27 100 1.3 0.60
Tertiary 7 3.9 (1.6–7.8) 7 4.5 (1.8–9.1) 0 0
Prefer not to answer 1 0.6 (0.0–3.0) 1 0.7 (0.0–3.5) 0 0
Marital status
Married (living together)
Married (living separately)
Cohabiting 3 1.7 (0.3–4.7) 2 1.3 (0.2–4.6) 1 3.7 (0.1–19.0) 1.5 0.44
Dating (living separately) 119 65.4 (58.0–72.3) 100 64.5 (56.4–72.0) 19 70.4 (49.8–86.2)
Single 59 32.4 (25.7–39.7) 52 33.6 (26.2–41.6) 7 25.9 (11.1–46.3)
Prefer not to answer 1 0.5 (0.1–3.7) 1 0.7 (0.0–3.5) 0 0
Food insecurity
Low 158 86.8 (81.0–91.4) 134 86.5 (80.0–91.4) 24 88.9 (70.8–97.6) 0.9 0.82
Medium 19 10.4 (6.4–15.8) 16 10.3 (6.0–16.2) 3 11.1 (2.4–29.2)
High 1 0.6 (0.0–3.7) 1 0.6 (0.1–3.6) 0 0
Prefer not to answer 4 2.2 (0.6–5.5) 4 2.6 (0.7–6.5) 0 0
Household income
R0–999 150 82.4 (76.1–87.7) 125 80.7 (73.5–86.5) 25 92.6 (75.7–99.1) 2.9 0.73
R1000–4999 8 4.4 (1.9–8.5) 8 5.2 (2.3–9.9) 0 0
R5000+ 1 0.6 (0.0–3.0) 1 0.7 (0.0–3.5) 0 0
Don’t know 19 10.4 (6.4–15.8) 17 11.0 (6.5–17.0) 2 7.4 (0.9–24.3)
Prefer not to answer 4 2.2 (0.6–5.5) 4 2.6 (0.7–6.5) 0 0
Received child grant
No 39 21.4 (15.7–28.1) 31 20.0 (14.0–27.2) 8 29.6 (13.8–50.2) 2.5 0.34
Yes 135 74.2 (67.2–80.4) 116 74.8 (67.2–81.5) 19 70.4 (49.8–86.2)
Don’t know 8 4.4 (1.9–8.5) 8 5.2 (2.3–9.9) 0 0
Received disability grant
N7 = 175; N8 = 148; N9 = 27
No 153 87.4 (81.6–91.6) 128 86.5 (79.9–91.5) 25 92.6 (75.7–99.1) 0.8 0.30
Yes 22 12.6 (8.0–18.4) 20 13.5 (8.5–20.1) 2 7.4 (0.9–24.3)
Received social grant
No 87 47.8 (40.4–55.3) 76 49.0 (40.9–57.2) 11 40.7 (22.4–61.2) 1.4 0.60
Yes 83 45.6 (38.2–53.1) 68 43.9 (35.9–52.1) 15 55.6 (35.3–74.5)
Don’t know 12 6.6 (3.5–11.2) 11 7.1 (3.6–12.3) 1 3.7 (0.1–19.0)
Prefer not to answer
Service Delivery point
Clinics 22 12.1 (7.7–17.7) 16 10.3 (6.0–16.2) 6 22.2 (8.6–42.3) 11.1 0.01
Youth Zones 42 23.1 (17.2–29.9) 31 20.0 (14.0–27.2) 11 40.7 (22.4–61.2)
High Schools 94 51.7 (44.1–59.1) 87 56.1 (47.9–64.1) 7 25.9 (11.1–46.3)
TVET colleges 24 13.2 (8.6–19.0) 21 13.6 (8.6–20.0) 3 11.1 (2.4–29.2)

The p-value of 0.05 was considered statistically significant is given in bold

p-values derived using Pearson Chi-squared test and considered the one stage cluster design

Proportions (%) for the columns reported as n/N (except if data is missing - denominator added in the n column) and the associated 95% CI; CI Confidence Interval