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. 2025 May 20;41(5):503–513. doi: 10.1007/s43188-025-00297-w

Table 7.

The summary of histopathological findings

Organ Group (No. of Animals)
Control 40% RYR
Examined 5 5
Brain
No finding noted 5 5
Urinary bladder
No finding noted 5 5
Gastrocnemius
No finding noted 5 5
Liver
 focal steatosis Number of affected 4 0
Stomach
 Focal glandular dilatation Number of affected 1 0
Lung
 Alveolar wall thickening Number of affected 5 5
 Alveolar congestion & edema Number of affected 5 5
 Focal peribronchial inflammatory cell infiltrates Number of affected 1 0
 Focal foamy macrophages infiltrates Number of affected 0 1
Kidney
 A few atrophy glomeruli Number of affected 5 5
 Protein casts Number of affected 5 4
 Focal interstitial inflammatory cell infiltrates Number of affected 2 2
 Cystic dilatation of tubules Number of affected 2 2
 Focal tubular degeneration Number of affected 1 0
 Focal areas of tubule basophilia Number of affected 0 1
Thyroid
 Minimal follicular cell hypertrophy & hyperplasia Number of affected 0 2