Table 4.
Results of the between laboratory validation study
| No. | Test substance | Lab 1 | Lab 2 | Lab 3 | Concordance | LLNA result | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDR | LDR | Result | CDR | LDR | Result | CDR | LDR | Result | ||||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||||||
| 1 | p-Benzoquinone | 100.0 | 0.0 | 90.2 | 4.0 | S | 98.2 | 1.9 | 96.0 | 0.0 | S | 100.0 | 0.0 | 81.8 | 8.7 | S | Yes | S |
| 2 | Lauryl gallate | – | – | – | – | - | 12.7 | 1.5 | 94.5 | 0.4 | S | 48.7 | 37.6 | 88.3 | 2.0 | S | No | S |
| 3 | Chloramine T trihydrate | 96.3 | 0.9 | 97.5 | 0.1 | S | 97.1 | 0.9 | 94.2 | 0.1 | S | 99.2 | 0.6 | 96.8 | 0.5 | S | Yes | S |
| 4 | 4-(Methylamino)phenol sulfate | 97.2 | 0.2 | 88.8 | 2.3 | S | 99.8 | 0.3 | 99.5 | 0.4 | S | 96.5 | 2.4 | 99.8 | 0.2 | S | Yes | S |
| 5 | 2-Mercaptobenzothiazole | 35.0 | 1.5 | 9.3 | 4.3 | S | 33.6 | 0.8 | 6.0 | 6.0 | S | 36.9 | 7.7 | 0.0 | 0.0 | S | Yes | S |
| 6 | Dihydroeugenol | 1.1 | 0.8 | 3.9 | 0.8 | NS | 6.0 | 0.2 | 3.5 | 2.4 | NS | 0.7 | 0.4 | 0.0 | 0.0 | NS | Yes | S |
| 7 | Palmitoyl chloride | 7.6 | 5.1 | 8.5 | 1.9 | NS | 23.2 | 2.4 | 40.7 | 1.3 | S | 7.0 | 4.6 | 0.0 | 0.0 | NS | No | S |
| 8 | Benzyl salicylate | 4.4 | 0.1 | 3.4 | 0.4 | NS | 0.7 | 0.7 | 4.2 | 4.2 | NS | 0.9 | 0.9 | 0.0 | 0.0 | NS | Yes | S |
| 9 | Cinnamaldehyde | 62.0 | 0.3 | 18.9 | 5.0 | S | 51.5 | 0.9 | 5.5 | 1.4 | S | 49.9 | 1.2 | 0.0 | 0.0 | S | Yes | S |
| 10 | Farnesal | 56.6 | 30.8 | 10.3 | 3.7 | S | 97.4 | 2.7 | 9.1 | 2.7 | S | 92.8 | 4.6 | 0.0 | 0.0 | S | Yes | S |
| 11 | Imidazolidinyl urea | 0.0 | 0.0 | 53.6 | 2.0 | S | 2.2 | 2.2 | 37.2 | 0.6 | S | 0.0 | 0.0 | 26.6 | 17.9 | S | Yes | S |
| 12 | Ethyl acrylate | 99.7 | 0.1 | 16.2 | 2.9 | S | 24.3 | 2.8 | 0.8 | 0.8 | S | 30.0 | 9.8 | 0.0 | 0.0 | S | Yes | S |
| 13 | Benzyl cinnamate | 1.8 | 0.3 | 4.4 | 1.9 | NS | 5.0 | 1.6 | 2.0 | 2.0 | NS | 0.0 | 0.0 | 0.0 | 0.0 | NS | Yes | S |
| 14 | Salicylic acid | 2.4 | 1.0 | 7.1 | 3.3 | NS | 6.4 | 0.1 | 2.6 | 2.6 | NS | 0.2 | 0.1 | 0.0 | 0.0 | NS | Yes | NS |
| 15 | Benzyl alcohol | 1.6 | 1.5 | 3.3 | 0.8 | NS | 0.0 | 0.0 | 4.5 | 4.5 | NS | 2.0 | 0.8 | 0.0 | 0.0 | NS | Yes | NS |
| 16 | Glycerol | 0.4 | 0.1 | 0.6 | 0.4 | NS | 2.9 | 0.7 | 2.1 | 2.1 | NS | 18.2 | 13.9 | 0.0 | 0.0 | S | No | NS |
| 17 | Isopropanol | 3.8 | 0.6 | 1.1 | 1.1 | NS | 4.2 | 0.8 | 3.5 | 3.5 | NS | 0.1 | 0.1 | 0.0 | 0.0 | NS | Yes | NS |
| 18 | Dimethyl isophthalate | 3.0 | 1.4 | 4.0 | 4.0 | NS | 2.1 | 2.1 | 10.8 | 2.1 | NS | 0.1 | 0.1 | 0.0 | 0.0 | NS | Yes | NS |
| 19 | Methyl salicylate | 6.4 | 0.6 | 3.9 | 1.6 | NS | 3.0 | 1.1 | 7.3 | 6.3 | NS | 1.7 | 1.6 | 0.9 | 0.9 | NS | Yes | NS |
| 20 | 4-Aminobenzoic acid | 2.5 | 0.5 | 91.1 | 5.1 | S | 2.1 | 2.1 | 62.0 | 25.7 | S | 1.2 | 0.5 | 95.4 | 4.7 | S | No | NS |
| Reproducibility (%) | 85.0 | |||||||||||||||||
CDR cysteine depletion rate, LDR lysine depletion rate