Table 3.

Univariable and multivariable analyses of weight gain following anamorelin administration

		OR	95% CI	P-value	OR	95% CI	P-value
Analysis of weight gain after 4 weeks of administration		Univariable analysis			Multivariable analysis
Age	≥ 76 years	1.00	0.55–1.81	0.99	1.03	0.53–1.98	0.94
Sex	Male	1.51	0.79–2.89	0.21	1.69	0.82–3.49	0.15
Number of chemotherapy lines	1st line	1.55	0.85–2.82	0.15	1.64	0.86–3.12	0.13
Gastrectomy before anamorelin administration	Performed	1.25	0.69–2.26	0.47	1.05	0.53–2.10	0.88
BMI	≤ 20 kg/m2	1.36	0.71–2.58	0.35	1.07	0.52–2.22	0.86
Hb	≥ 10 g/dL	0.71	0.37–1.34	0.29	0.88	0.44–1.76	0.72
mGPS	0	1.06	0.57–2.00	0.85	1.00	0.46–2.15	0.99
NLR	≤ 4.0	1.06	0.56–2.02	0.85	1.42	0.64–3.16	0.38
LAR	≤ 300	1.61	0.84–3.08	0.15	1.83	0.83–4.02	0.14
CAR	≤ 0.3	1.02	0.52–1.98	0.96	0.77	0.35–1.67	0.50
Analysis of weight gain after 8 weeks of administration		Univariable analysis			Multivariable analysis
Age	≥ 76 years	1.10	0.56–2.17	0.78	1.72	0.76–3.86	0.19
Sex	Male	1.35	0.65–2.79	0.42	1.18	0.49–2.83	0.71
Number of chemotherapy lines	1st line	1.17	0.59–2.31	0.65	1.69	0.77–3.68	0.19
Gastrectomy before anamorelin administration	Performed	0.86	0.44–1.69	0.66	0.54	0.23–1.26	0.15
BMI	≤ 20 kg/m2	1.97	0.97–3.99	0.061	3.14	1.27–7.79	0.013
Hb	≥ 10 g/d	1.66	0.83–3.35	0.15	2.62	1.16–5.94	0.021
mGPS	0	1.31	0.64–2.70	0.46	1.07	0.44–2.64	0.88
NLR	≤ 4.0	1.43	0.67–3.05	0.35	1.08	0.40–2.93	0.88
LAR	≤ 300	0.77	0.39–1.55	0.47	0.89	0.36–2.22	0.80
CAR	≤ 0.3	1.69	0.78–3.67	0.18	1.41	0.56–3.52	0.46
Analysis of weight gain after 12 weeks of administration		Univariable analysis			Multivariable analysis
Age	≥ 76 years	1.32	0.61–2.85	0.48	1.76	0.70–4.47	0.23
Sex	Male	1.11	0.50–2.47	0.79	1.16	0.42–3.22	0.77
Number of chemotherapy lines	1st line	1.38	0.64–3.00	0.42	2.13	0.84–5.38	0.11
Gastrectomy before anamorelin administration	Performed	1.05	0.50–2.22	0.90	0.46	0.17–1.25	0.13
BMI	≤ 20 kg/m2	2.44	1.09–5.44	0.029	3.89	1.33–11.35	0.013
Hb	≥ 10 g/dL	1.46	0.66–3.23	0.35	1.88	0.73–4.86	0.19
mGPS	0	1.57	0.70–3.52	0.27	1.83	0.66–5.08	0.25
NLR	≤ 4.0	3.00	1.27–7.07	0.012	3.51	1.12–11.02	0.031
LAR	≤ 300	0.55	0.25–1.21	0.14	1.10	0.38–3.22	0.86
CAR	≤ 0.3	1.08	0.48–2.46	0.85	0.75	0.26–2.14	0.59

BMI body mass index, Hb hemoglobin, mGPS modified Glasgow Prognostic Score, NLR neutrophil-to-lymphocyte ratio, LAR lymphocyte-to-albumin ratio, CAR C-reactive protein-to-albumin ratio