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. 2025 Aug 12;16:1587727. doi: 10.3389/fpsyt.2025.1587727

Table 3.

Functional enrichments of networks based on GNAO1, GNB1 and GNAI1 interactions.

Network Proteins Network stats Database Description Strength1 FDR2
1 Diagram showing three interconnected nodes labeled GNAI1, GNB1, and GNAO1, forming a triangle. Each node has a distinct color: blue, green, and red respectively. Multiple colored lines connect the nodes. GNAO1
GNB1
GNAI1		 number of nodes: 3
number of edges: 3
average node degree: 2
avg. local clustering coefficient: 1
expected number of edges: 0
PPI enrichment p-value: 0.0029		 Gene Ontology 1#
GO:0007188
Adenylate cyclase-modulating G protein-coupled receptor signalling		 1.93 0.0263
KEGG Pathways 1#
hsa:04727
GABAergic synapse		 2.19 0.0194
2 Network diagram illustrating interactions between various nodes labeled as GNAO1, RGS4, RGS7, RGS16, DRD2, GNB5, GNG2, GNB4, GNB1, RIC8A, and ADRA2A. Nodes are connected by multicolored lines, indicating relationships or interactions. GNAO1
GNB1
GNB4
GNG2
GNB5
ADRA2A
RGS16
RGS4
RGS7
DRD2
RIC8A		 number of nodes: 11
number of edges: 46
average node degree: 8.36
avg. local clustering coefficient: 0.893
expected number of edges:12
PPI enrichment p-value: 1.15e-13		 Gene Ontology 1#
GO:0060160
Negative regulation of dopamine receptor signaling pathway		 3.08 0.0014
KEGG Pathways 1#
hsa04727- GABAergic synapse		 1.93 1.40e-05
3 Network diagram depicting interactions between proteins labeled PDCL, GNAS, GNB1, GNG5, GNG13, GNAI2, GNG2, GNG3, GNGT1, GNAI3, and GNG12. Lines of various colors connect the nodes, representing relationships among the proteins. GNB1
GNG5
GNG12
GNG13
GNG2
GNG3
GNGT1
GNAI2
GNAS
GNAI3
PDCL		 number of nodes: 11
number of edges: 52
average node degree: 9.45
avg. local clustering coefficient: 0.958
expected number of edges: 14
PPI enrichment p-value: 1.42e-14		 Gene Ontology 1#
GO:0007191
Adenylate cyclase-activating dopamine receptor signaling pathway		 2.73 0.00019
KEGG Pathways 3#
hsa04727-
GABAergic synapse		 2.28 1.97e-18
4 Network diagram illustrating interactions between various proteins. Nodes are labeled with protein names like GNAI1, GNB1, and DRD2, connected by multicolored lines representing potential interactions. Central node is GNG2, with connections to several others. GNAI1
LPAR1
GNG2
GABBR2
GNB1
DRD2
CNR1
S1PR1
RGS14
NPY1R
PTGER3		 number of nodes: 11
number of edges: 52
average node degree: 9.45
avg. local clustering coefficient: 0.958
expected number of edges: 14
PPI enrichment p-value: 1.42e-14		 Gene Ontology 1#
GO:0033602
Negative regulation of dopamine secretion		 2.86 0.0067
KEGG Pathways 2#
hsa04727
GABAergic synapse		 1.93 1.05e-05
Diagram showing types of interactions: known interactions include curated databases (blue) and experimentally determined (pink), predicted interactions include gene neighborhood (green), gene fusions (red), and gene co-occurrence (blue), and others include text mining (yellow), co-expression (black), and protein homology (purple). 1Strength: Log10(observed/expected). This measure describes how large the enrichment effect is. It’s the ratio between i) the number of proteins in your network that are annotated with a term and ii) the number of proteins that we expect to be annotated with this term in a random network of the same size.
2False Discovery Rate: This measure describes how significant the enrichment is. Shown are p-values corrected for multiple testing within each category using the Benjamini–Hochberg procedure.