TABLE 4.
Genotype distribution and comparison results with allele frequency of the study population in the ADR research group.
| SNP Id | Observation subgroup n = 190 (%) | Control subgroup n = 190 (%) | χ2 | P-value | OR (95% CI) |
|---|---|---|---|---|---|
| CYP2D6*10 (rs1065852, C>T) | |||||
| CC | 86 (45.26) | 75 (39.47) | |||
| CT | 68 (35.79) | 84 (44.21) | |||
| TT | 36 (18.95) | 31 (16.32) | |||
| CT + TT | 104 (54.74) | 115 (60.53) | 3.160 | 0.368* | 1.049 (0.921–1.195) |
| Allelic | |||||
| C | 240 (63.16) | 234 (61.58) | |||
| T | 140 (36.84) | 146 (38.42) | 0.202 | 0.653 | 1.070 (0.798–1.435) |
| OPRM1 (rs1799971, A>G) | |||||
| AA | 99 (52.11) | 72 (37.89) | |||
| AG | 66 (34.74) | 92 (48.42) | |||
| GG | 25 (13.16) | 26 (13.68) | |||
| AG + GG | 91 (47.90) | 118 (62.10) | 10.834 | 0.013* | 1.164 (1.021–1.327) |
| Allelic | |||||
| A | 264 (69.47) | 236 (62.11) | |||
| G | 116 (30.53) | 144 (37.89) | 4.583 | 0.032 | 1.389 (1.028–1.876) |
| ABCB1(rs1045642, C>T) | |||||
| CC | 64 (33.68) | 72 (37.89) | |||
| CT | 95 (50.00) | 90 (47.37) | |||
| TT | 31 (16.32) | 28 (14.74) | |||
| CT + TT | 126 (66.32) | 118 (62.11) | 1.353 | 0.717* | 0.943 (0.826–1.077) |
| Allelic | |||||
| C | 223 (58.68) | 234 (61.58) | |||
| T | 157 (41.32) | 146 (38.42) | 1.127 | 0.288 | 0.852 (0.634–1.145) |
| CYP3A5*3 (rs776746, A>G) | |||||
| AA | 28 (14.74) | 22 (11.58) | |||
| AG | 60 (31.58) | 57 (30.00) | |||
| GG | 102 (53.68) | 111 (58.42) | |||
| AG + GG | 162 (85.26) | 168 (88.42) | 1.236 | 0.744* | 1.066 (0.911–1.246) |
| Allelic | |||||
| A | 116 (30.53) | 101 (26.58) | |||
| G | 264 (69.47) | 279 (73.42) | 1.451 | 0.228 | 1.214 (0.885–1.664) |
Note: * indicates calculations based on grouped phenotypes: CT + TT vs CC and AG + GG vs AA.