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. 2025 Apr 7;60(9):2223–2235. doi: 10.1007/s00127-025-02888-2

Table 4.

Adjusted odds ratios for adolescent loneliness and low resilience at baseline associated with anxiety and depression in young adulthood: additive and multiplicative interaction

Loneliness High resilience Low Resilience RERI (95% CI)¹
Anxiety symptoms (HADS-A)
Total N OR (95% CI) Total N OR (95% CI)
Rarely lonely 925 201 1.00 296 91 1.13 (0.81–1.58)ORB -0.07 (-1.83-1.69)
Very lonely 32 14 2.05 (0.96–4.35)ORA 92 46 2.11 (1.28–3.47)ORAB
Depression symptoms (HADS-D)
Rarely lonely 925 58 1.00 295 45 1.81 (1.11–2.93)ORB -0.87 (-3.49-1.76)
Very lonely 32 7 2.36 (0.87–6.39)ORA 93 20 2.31 (1.17–4.55)ORAB
Anxiety and Depression (HADS-T)
Rarely lonely 931 48 1.00 299 36 1.57 (0.92–2.67)ORB 0.13 (-2.39-2.65)
Very lonely 32 4 1.87 (0.59–5.90)ORA 93 19 2.57 (1.26–5.23)ORAB

¹The relative excess risk due to interaction (RERI) between adolescent loneliness (A) and low resilience (B) was calculated using the formula: RERI = ORAB– ORA– ORB + 1

Adjusted for age, gender, relationship with family, SES, school satisfaction, and self-esteem at baseline

Measure of interaction on the multiplicative scale (HADS-A): 0.91 (95% CI. 0.37–2.23)

Measure of interaction on the multiplicative scale (HADS-D): 0.54 (95% CI 0.18–1.82)

Measure of interaction on the multiplicative scale (HADS-T): 0.88 (95% CI 0.26–3.62)