Table 1:
Baseline characteristics for the University of Michigan test and the University of Chicago validation cohorts
| University of Michigan (n=350) | University of Chicago (n=92) | |
|---|---|---|
| Clinical characteristics | ||
| Age, years, mean ± SD | 66.3 ± 10.7 | 64.7 ± 10.9 |
| Male sex, n (%) | 184 (52.6) | 56 (60.9) |
| Body mass index (BMI), kg/m2, mean ± SD | 30.5 ± 6.5 | 30.7 ± 7.3 |
| Ever-smoker, n (%) | 193 (55.1) | 57 (62.0) |
| Race, n (%) | ||
| White | 292 (83.4) | 73 (79.3) |
| Black | 38 (10.9) | 13 (14.1) |
| Hispanic | 5 (1.4) | 2 (2.2) |
| Asian/Pacific Islander | 9 (2.6) | 3 (3.3) |
| Other/Unknown | 6 (1.7) | 1 (1.1) |
| ILD classification, n (%) | ||
| IPF | 151 (43.1) | 40 (43.5) |
| CTD-ILD | 118 (33.7) | 18 (19.6) |
| IIP | 53 (15.1) | 15 (16.3) |
| fHP | 28 (8.0) | 19 (20.7) |
| PFT characteristics | ||
| Forced vital capacity (FVC), L, mean ± SD | 2.6 ± 0.9 | 2.4 ± 0.8 |
| FVC % predicted, mean ± SD | 71.9 ± 19.1 | 64.2 ± 17.3 |
| Diffusion capacity (DLCO), mm/min/mmHg, mean ± SD | 13.0 ± 5.4 | 10.8 ± 5.8 |
| DLCO % predicted, mean ± SD | 54.9 ± 19.2 | 49.1 ± 19.4 |
| qCT characteristics | ||
| Lung volume, L, mean ± SD | 3.6 ± 1.2 | 3.4 ± 1.0 |
| Pulmonary vascular-related structure volume, L, mean ± SD | 0.2 ± 0.07 | 0.2 ± 0.07 |
| % Reticular opacity, mean ± SD | 6.4 ± 5.6 | 6.5 ± 5.2 |
| % Ground glass opacity, mean ± SD | 19.0 ± 20.6 | 24.2 ± 22.5 |
| % Honeycombing, mean ± SD | 0.5 ± 1.3 | 0.2 ± 0.7 |
Definitions of abbreviations: CTD = connective tissue disease; fHP = fibrotic hypersensitivity pneumonitis; IIP = idiopathic interstitial pneumonia, ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; PFT = pulmonary function test; qCT = quantitative computed tomography