Table 2:

Change in qCT measures and association between continuous and categorical change in qCT measures and 2-year TFS in University of Michigan test and University of Chicago validation cohorts

	University of Michigan				University of Chicago
Continuous qCT measure (%)	Mean ± S.D.	HR*	95% CI	p	Mean ± S.D.	HR*	95% CI	p
Lung Volume	−0.2 ± 18.0	1.04	1.03–1.05	<0.001	−1.8 ± 19.7	1.03	1.01–1.05	0.003
Vascular Volume	4.4 ± 23.4	1.01	1.00–1.02	0.134	16.2 ± 42.4	1.02	1.01–1.03	<0.001
Reticular Opacity	0.4 ± 5.8	1.09	1.06–1.12	<0.001	0.0 ± 5.9	1.07†	0.98–1.16	0.133
Ground Glass	−0.2 ± 15.6	1.02	1.01–1.04	<0.001	3.9 ± 19.9	1.02	1.00–1.04	0.022
Honeycombing	0.2 ± 1.5	1.12	1.03–1.23	0.010	−0.1 ± 0.7	1.01	0.43–2.35	0.989
Categorical qCT measure (%)	“High” strata n (%)	HR*	95% CI	p	“High” strata n (%)	HR*	95% CI	p
Lung Volume	105 (30)	3.20	2.07–4.94	<0.001	35 (38)	2.75	1.41–5.36	0.003
Vascular Volume	286 (82)	2.25	1.15–4.38	0.018	82 (89)	0.88	0.31–2.47	0.802
Reticular Opacity	45 (13)	2.87	1.76–4.68	<0.001	14 (15)	1.40	0.58–3.36	0.457
Ground Glass	40 (11)	2.18	1.25–3.79	0.006	21 (23)	3.40	1.55–7.48	0.002
Honeycombing	94 (27)	1.90	1.24–2.92	0.003	12 (13)	1.28	0.45–3.62	0.646

All models adjusted for presence of connective tissue disease (CTD), sex, race, smoking history and baseline body mass index (BMI), age, percent predicted forced vital capacity (FVC), percent predicted diffusion capacity of the lungs for carbon monoxide (DLCO), and CALIPER-derived measures total lung volume, pulmonary vascular-related structure volume and percent ground glass opacity, reticular opacity and honeycombing

Lung volume and vascular volume (pulmonary vascular-related structure volume) are reported as relative change, while reticular opacity, ground glass opacity and honeycombing are reported as absolute change

^*Per unit change in qCT measures when modeled continuously and for “high” vs “low” strata after dichotomization at the optimal threshold

^†Proportional hazards assumption violated