Table 3.
Adjusted Association between Quantitative Computed Tomography Measure of Progressive Pulmonary Fibrosis Status and 2-Year Transplant-Free Survival in Pooled Cohort, Stratified by Interstitial Lung Disease Subtype
| Cohort (n) | qctPPF(+) (n/%) | HR | 95% CI | P Value |
|---|---|---|---|---|
| Pooled (442) | 204 (46.2) | 4.28 | 2.90–6.31 | <0.001 |
| Non-IPF ILD (251) | 110 (43.8) | 6.40 | 3.50–11.73 | <0.001 |
| IPF (191) | 94 (49.2) | 3.09 | 1.78–5.36 | <0.001 |
| CTD-ILD (136) | 61 (44.9) | 5.58 | 2.22–13.99 | 0.001 |
| Other fibrotic ILD (115) | 49 (42.6) | 8.54 | 3.38–21.61 | <0.001 |
Definition of abbreviations: CTD = connective tissue disease; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; qctPPF = quantitative computed tomography measurement of progressive pulmonary fibrosis.
All models adjusted for sex, race, smoking history, baseline body mass index, age, percent predicted FVC, percent predicted DlCO, and CALIPER-derived measures of total lung volume, pulmonary vascular-related structure volume, and percent ground-glass opacity, reticular opacity, and honeycombing.