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. 2025 Aug 12;12:1616221. doi: 10.3389/fmolb.2025.1616221

FIGURE 3.

Diagram of the Wnt/β-catenin signaling pathway including microRNAs and their effects. Wnt protein binds to receptors LRP and Frizzled, inhibiting GSK-3β through Dishevelled. β-catenin accumulates and activates target genes. MicroRNAs, such as miR-217 and miR-148a, regulate components like β-catenin and GSK-3β. Specific microRNAs, like miR-3127-5p and miR-1260b, interact at various pathway points, impacting gene expression. The pathway involves elements like axin and APC, with inhibiting or stimulating effects by respective microRNAs indicated by colored arrows and symbols.

Combination Therapies Targeting the miRNA-WNT-Flavonoid Triad. Overview of combination therapeutic strategies employing flavonoids, microRNAs (miRNAs), and WNT signaling modulation. This schematic illustrates how combined approaches using specific flavonoids and miRNAs enhance therapeutic efficacy by simultaneously targeting specific components of the oncogenic WNT pathway. The image was created with BioRender.com.