Table 11. Inhibition concentrations against pjDHFR and hDHFR and selectivity ratios.
| Compd | IC50 (nM) | ||
|---|---|---|---|
| pjDHFR | hDHFR | Selectivity ratio [hDHFR/pjDHFR] | |
| 195 | 35 | 511 | 15 |
| 196 | 84 | 2046 | 24 |
| 197 | 74 | 579 | 8 |
| 198 | 73 | 1130 | 15 |
| 199 | 81 | 811 | 10 |
| TMP | 92 | 24 500 | 266 |
| PTX | 41 | 2 | 0.05 |
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